1-Pyrenebutyric acid

Name: 1-Pyrenebutyric acid
Brand: MedChemExpress
SKU: HY-W103047
Rating: 4.5 (1 reviews)

Cat. No.: HY-W103047 Purity: 97.49%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Pyrenebutyric acid is a fluorescence probe that can be used in fluorescence determination of DNA. 1-Pyrenebutyric acid can be used as a linker for biomolecules to form a self-assembled monolayer on grapheme.

For research use only. We do not sell to patients.

1-Pyrenebutyric acid Chemical Structure

CAS No. : 3443-45-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 30	In-stock	Estimated Time of Arrival: December 31
5 g	USD 86	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

288.34

Formula

C₂₀H₁₆O₂

CAS No.

3443-45-6

Appearance

Solid

Color

Light yellow to light brown

SMILES

C1=CC2=C3C(=C1)C=CC4=C(CCCC(=O)O)C=CC(=C43)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (346.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4681 mL	17.3406 mL	34.6813 mL
5 mM	0.6936 mL	3.4681 mL	6.9363 mL
10 mM	0.3468 mL	1.7341 mL	3.4681 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (8.67 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 97.49%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) HNMR (131 KB) RP-HPLC (452 KB) MS (154 KB)

Handling Instructions (2659 KB)

References

[1]. Wang L, et, al. Fluorescence determination of DNA with 1-pyrenebutyric acid nanoparticles coated with beta-cyclodextrin as a fluorescence probe. Spectrochim Acta A Mol Biomol Spectrosc. 2005 Apr;61(6):1201-5. [Content Brief]

[2]. Hinnemo M, et, al. On Monolayer Formation of Pyrenebutyric Acid on Graphene. Langmuir. 2017 Apr 18;33(15):3588-3593. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4681 mL	17.3406 mL	34.6813 mL	86.7032 mL
	5 mM	0.6936 mL	3.4681 mL	6.9363 mL	17.3406 mL
	10 mM	0.3468 mL	1.7341 mL	3.4681 mL	8.6703 mL
	15 mM	0.2312 mL	1.1560 mL	2.3121 mL	5.7802 mL
	20 mM	0.1734 mL	0.8670 mL	1.7341 mL	4.3352 mL
	25 mM	0.1387 mL	0.6936 mL	1.3873 mL	3.4681 mL
	30 mM	0.1156 mL	0.5780 mL	1.1560 mL	2.8901 mL
	40 mM	0.0867 mL	0.4335 mL	0.8670 mL	2.1676 mL
	50 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7341 mL
	60 mM	0.0578 mL	0.2890 mL	0.5780 mL	1.4451 mL
	80 mM	0.0434 mL	0.2168 mL	0.4335 mL	1.0838 mL
	100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8670 mL