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  4. 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 

Cat. No.: HY-W096093 Purity: ≥98.0%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Help & FAQs

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Chemical Structure

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Chemical Structure

CAS No. : 1035373-85-3

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride:

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Description

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

260.20

Formula

C10H23Cl2NO2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NCCOCCOCCCCCCCl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (160.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8432 mL 19.2160 mL 38.4320 mL
5 mM 0.7686 mL 3.8432 mL 7.6864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.71%

Data Sheet (266 KB) SDS (393 KB)

COA (241 KB) HNMR (133 KB) RP-HPLC (227 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8432 mL 19.2160 mL 38.4320 mL 96.0799 mL
5 mM 0.7686 mL 3.8432 mL 7.6864 mL 19.2160 mL
10 mM 0.3843 mL 1.9216 mL 3.8432 mL 9.6080 mL
15 mM 0.2562 mL 1.2811 mL 2.5621 mL 6.4053 mL
20 mM 0.1922 mL 0.9608 mL 1.9216 mL 4.8040 mL
25 mM 0.1537 mL 0.7686 mL 1.5373 mL 3.8432 mL
30 mM 0.1281 mL 0.6405 mL 1.2811 mL 3.2027 mL
40 mM 0.0961 mL 0.4804 mL 0.9608 mL 2.4020 mL
50 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9216 mL
60 mM 0.0641 mL 0.3203 mL 0.6405 mL 1.6013 mL
80 mM 0.0480 mL 0.2402 mL 0.4804 mL 1.2010 mL
100 mM 0.0384 mL 0.1922 mL 0.3843 mL 0.9608 mL
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2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride Related Classifications

Help & FAQs
  • How should lyophilized recombinant proteins be reconstituted and stored?

    1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.

  • How should solution-form recombinant proteins be stored?

    1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that

  • Why is it necessary to add carrier proteins?

    Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.

  • Carrier protein types and options?

    In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

Keywords:

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine1035373-85-3PROTAC LinkersInhibitorinhibitorinhibit

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2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
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