2. Others Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds HSV Hexokinase Apoptosis
  4. 2-Deoxy-D-glucose-13C

2-Deoxy-D-glucose-13C  (Synonyms: 2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C)

Cat. No.: HY-13966S2 Purity: ≥98.0%
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2-Deoxy-D-glucose-13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

For research use only. We do not sell to patients.

2-Deoxy-D-glucose-<sup>13</sup>C Chemical Structure

2-Deoxy-D-glucose-13C Chemical Structure

CAS No. : 201612-55-7

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1 mg USD 140 In-stock
5 mg USD 360 In-stock
10 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Deoxy-D-glucose-13C:

2-Deoxy-D-glucose-13C Related Antibodies

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Description

2-Deoxy-D-glucose-13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Deoxy-D-glucose-13C Related Antibodies
Molecular Weight

165.15

Formula

C513CH12O5
CAS No.
Unlabeled CAS

154-17-6
Appearance

Solid

Color

White to off-white

SMILES

O=[13CH]C[C@@H](O)[C@H](O)[C@H](O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (605.51 mM)

DMSO : 100 mg/mL (605.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.5510 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.0551 mL 30.2755 mL 60.5510 mL 151.3775 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL 30.2755 mL
10 mM 0.6055 mL 3.0276 mL 6.0551 mL 15.1378 mL
15 mM 0.4037 mL 2.0184 mL 4.0367 mL 10.0918 mL
20 mM 0.3028 mL 1.5138 mL 3.0276 mL 7.5689 mL
25 mM 0.2422 mL 1.2110 mL 2.4220 mL 6.0551 mL
30 mM 0.2018 mL 1.0092 mL 2.0184 mL 5.0459 mL
40 mM 0.1514 mL 0.7569 mL 1.5138 mL 3.7844 mL
50 mM 0.1211 mL 0.6055 mL 1.2110 mL 3.0276 mL
60 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.5230 mL
80 mM 0.0757 mL 0.3784 mL 0.7569 mL 1.8922 mL
100 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.5138 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Deoxy-D-glucose-13C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Deoxy-D-glucose-13C201612-55-72-DG-13C2-Deoxy-D-arabino-hexose-13CD-Arabino-2-deoxyhexose-13CIsotope-Labeled CompoundsHSVHexokinaseApoptosisHerpes simplex virusInhibitorinhibitorinhibit

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