2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. 2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..

For research use only. We do not sell to patients.

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2-Furoyl-LIGRLO-amide Chemical Structure

2-Furoyl-LIGRLO-amide Chemical Structure

CAS No. : 729589-58-6

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5 mg USD 314 In-stock
10 mg USD 534 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2-Furoyl-LIGRLO-amide:

2-Furoyl-LIGRLO-amide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2-Furoyl-LIGRLO-amide

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

IC50 & Target

PAR2

 

In Vitro

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Furoyl-LIGRLO-amide Related Antibodies
In Vivo

Furoyl-LIGRLO-amide (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3-/- mice. But it decreases significantly the number of scratches in WT mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male (2/3-month-old) Trpv3-/- and WT mice[3]
Dosage: 10 μg
Administration: Injected intradermally at the nape of the neck
Result: Was involved in PAR2- induced acute itch.
Molecular Weight

777.95

Formula

C36H63N11O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (64.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2854 mL 6.4271 mL 12.8543 mL
5 mM 0.2571 mL 1.2854 mL 2.5709 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (64.27 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

COA (248 KB) LCMS (119 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2854 mL 6.4271 mL 12.8543 mL 32.1357 mL
5 mM 0.2571 mL 1.2854 mL 2.5709 mL 6.4271 mL
10 mM 0.1285 mL 0.6427 mL 1.2854 mL 3.2136 mL
15 mM 0.0857 mL 0.4285 mL 0.8570 mL 2.1424 mL
20 mM 0.0643 mL 0.3214 mL 0.6427 mL 1.6068 mL
25 mM 0.0514 mL 0.2571 mL 0.5142 mL 1.2854 mL
30 mM 0.0428 mL 0.2142 mL 0.4285 mL 1.0712 mL
40 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8034 mL
50 mM 0.0257 mL 0.1285 mL 0.2571 mL 0.6427 mL
60 mM 0.0214 mL 0.1071 mL 0.2142 mL 0.5356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Furoyl-LIGRLO-amide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Furoyl-LIGRLO-amide729589-58-6Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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