2. Metabolic Enzyme/Protease Cytoskeleton
  3. Endogenous Metabolite Integrin
  4. 2-Methylbutyrylcarnitine chloride

2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine.

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2-Methylbutyrylcarnitine chloride Chemical Structure

2-Methylbutyrylcarnitine chloride Chemical Structure

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10 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methylbutyrylcarnitine chloride:

2-Methylbutyrylcarnitine chloride Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine[1].

Molecular Weight

281.78

Formula

C12H24ClNO4
Appearance

Solid

SMILES

CCC(C)C(O[C@H](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5489 mL 17.7443 mL 35.4887 mL
5 mM 0.7098 mL 3.5489 mL 7.0977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5489 mL 17.7443 mL 35.4887 mL 88.7217 mL
5 mM 0.7098 mL 3.5489 mL 7.0977 mL 17.7443 mL
10 mM 0.3549 mL 1.7744 mL 3.5489 mL 8.8722 mL
15 mM 0.2366 mL 1.1830 mL 2.3659 mL 5.9148 mL
20 mM 0.1774 mL 0.8872 mL 1.7744 mL 4.4361 mL
25 mM 0.1420 mL 0.7098 mL 1.4195 mL 3.5489 mL
30 mM 0.1183 mL 0.5915 mL 1.1830 mL 2.9574 mL
40 mM 0.0887 mL 0.4436 mL 0.8872 mL 2.2180 mL
50 mM 0.0710 mL 0.3549 mL 0.7098 mL 1.7744 mL
60 mM 0.0591 mL 0.2957 mL 0.5915 mL 1.4787 mL
80 mM 0.0444 mL 0.2218 mL 0.4436 mL 1.1090 mL
100 mM 0.0355 mL 0.1774 mL 0.3549 mL 0.8872 mL
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2-Methylbutyrylcarnitine chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MethylbutyrylcarnitineEndogenous MetaboliteIntegringutmetaboliteα2β1plateletscPLA2hyperresponsivenessthrombus formationmiceInhibitorinhibitorinhibit

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