2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3’-Azido-3’-deoxyuridine

3’-Azido-3’-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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3’-Azido-3’-deoxyuridine Chemical Structure

3’-Azido-3’-deoxyuridine Chemical Structure

CAS No. : 70580-88-0

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
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3’-Azido-3’-deoxyuridine Related Antibodies

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Description

3’-Azido-3’-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Molecular Weight

269.21

Formula

C9H11N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (464.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7146 mL 18.5729 mL 37.1457 mL
5 mM 0.7429 mL 3.7146 mL 7.4291 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7146 mL 18.5729 mL 37.1457 mL 92.8643 mL
5 mM 0.7429 mL 3.7146 mL 7.4291 mL 18.5729 mL
10 mM 0.3715 mL 1.8573 mL 3.7146 mL 9.2864 mL
15 mM 0.2476 mL 1.2382 mL 2.4764 mL 6.1910 mL
20 mM 0.1857 mL 0.9286 mL 1.8573 mL 4.6432 mL
25 mM 0.1486 mL 0.7429 mL 1.4858 mL 3.7146 mL
30 mM 0.1238 mL 0.6191 mL 1.2382 mL 3.0955 mL
40 mM 0.0929 mL 0.4643 mL 0.9286 mL 2.3216 mL
50 mM 0.0743 mL 0.3715 mL 0.7429 mL 1.8573 mL
60 mM 0.0619 mL 0.3095 mL 0.6191 mL 1.5477 mL
80 mM 0.0464 mL 0.2322 mL 0.4643 mL 1.1608 mL
100 mM 0.0371 mL 0.1857 mL 0.3715 mL 0.9286 mL
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3’-Azido-3’-deoxyuridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3’-Azido-3’-deoxyuridine70580-88-0Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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