3-O-Beta-D-Glucopyranosylplatycodigenin

Name: 3-O-Beta-D-Glucopyranosylplatycodigenin
Brand: MedChemExpress
SKU: HY-N3523
Rating: 4.5 (1 reviews)

Cat. No.: HY-N3523 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

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3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM.

For research use only. We do not sell to patients.

3-O-Beta-D-Glucopyranosylplatycodigenin Chemical Structure

CAS No. : 38337-25-6

Size	Price	Stock	Quantity
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HSC-T6	IC₅₀	13.36 μM Compound: 150	Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against rat HSC-T6 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 29353722]

Molecular Weight

682.84

Formula

C₃₆H₅₈O₁₂

CAS No.

38337-25-6

Appearance

Solid

Color

White to off-white

SMILES

OCC1([C@@]2([H])[C@@]([C@]3([H])[C@](C)([C@]4(C([C@@]5([H])[C@](C(O)=O)(CCC(C)(C)C5)[C@H](O)C4)=CC3)C)CC2)(C[C@H](O)[C@@H]1O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)CO)C)CO

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (146.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4645 mL	7.3224 mL	14.6447 mL
5 mM	0.2929 mL	1.4645 mL	2.9289 mL
10 mM	0.1464 mL	0.7322 mL	1.4645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (256 KB) HNMR (149 KB) CNMR (153 KB) RP-HPLC (147 KB) MS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Zhan Q, et al Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells. Molecules. 2012 Dec 13;17(12):14899-907. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4645 mL	7.3224 mL	14.6447 mL	36.6118 mL
	5 mM	0.2929 mL	1.4645 mL	2.9289 mL	7.3224 mL
	10 mM	0.1464 mL	0.7322 mL	1.4645 mL	3.6612 mL
	15 mM	0.0976 mL	0.4882 mL	0.9763 mL	2.4408 mL
	20 mM	0.0732 mL	0.3661 mL	0.7322 mL	1.8306 mL
	25 mM	0.0586 mL	0.2929 mL	0.5858 mL	1.4645 mL
	30 mM	0.0488 mL	0.2441 mL	0.4882 mL	1.2204 mL
	40 mM	0.0366 mL	0.1831 mL	0.3661 mL	0.9153 mL
	50 mM	0.0293 mL	0.1464 mL	0.2929 mL	0.7322 mL
	60 mM	0.0244 mL	0.1220 mL	0.2441 mL	0.6102 mL
	80 mM	0.0183 mL	0.0915 mL	0.1831 mL	0.4576 mL
	100 mM	0.0146 mL	0.0732 mL	0.1464 mL	0.3661 mL