2. Metabolic Enzyme/Protease Neuronal Signaling
  3. COMT
  4. 3-O-Methyltolcapone

3-O-Methyltolcapone  (Synonyms: Ro 40-7591)

Cat. No.: HY-100642 Purity: 99.95%
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3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease.

For research use only. We do not sell to patients.

3-O-Methyltolcapone Chemical Structure

3-O-Methyltolcapone Chemical Structure

CAS No. : 134612-80-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-O-Methyltolcapone:

3-O-Methyltolcapone Related Antibodies

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Description

3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].

IC50 & Target

COMT[1][2]
Molecular Weight

287.27

Formula

C15H13NO5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC([N+]([O-])=O)=C(O)C(OC)=C1)C2=CC=C(C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (348.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4810 mL 17.4052 mL 34.8105 mL
5 mM 0.6962 mL 3.4810 mL 6.9621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4810 mL 17.4052 mL 34.8105 mL 87.0261 mL
5 mM 0.6962 mL 3.4810 mL 6.9621 mL 17.4052 mL
10 mM 0.3481 mL 1.7405 mL 3.4810 mL 8.7026 mL
15 mM 0.2321 mL 1.1603 mL 2.3207 mL 5.8017 mL
20 mM 0.1741 mL 0.8703 mL 1.7405 mL 4.3513 mL
25 mM 0.1392 mL 0.6962 mL 1.3924 mL 3.4810 mL
30 mM 0.1160 mL 0.5802 mL 1.1603 mL 2.9009 mL
40 mM 0.0870 mL 0.4351 mL 0.8703 mL 2.1757 mL
50 mM 0.0696 mL 0.3481 mL 0.6962 mL 1.7405 mL
60 mM 0.0580 mL 0.2901 mL 0.5802 mL 1.4504 mL
80 mM 0.0435 mL 0.2176 mL 0.4351 mL 1.0878 mL
100 mM 0.0348 mL 0.1741 mL 0.3481 mL 0.8703 mL
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3-O-Methyltolcapone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-Methyltolcapone134612-80-9Ro 40-7591COMTCatechol-O-methyltransferaseMetaboliteTolcaponeblood-brainbarrierParkinson'sdiseaseInhibitorinhibitorinhibit

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