2. Metabolic Enzyme/Protease Neuronal Signaling
  3. COMT
  4. 3-O-Methyltolcapone

3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease.

For research use only. We do not sell to patients.

3-O-Methyltolcapone Chemical Structure

3-O-Methyltolcapone Chemical Structure

CAS No. : 134612-80-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-O-Methyltolcapone:

3-O-Methyltolcapone Related Antibodies

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Description

3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].

IC50 & Target

COMT[1][2]
Molecular Weight

287.27

Formula

C15H13NO5
CAS No.
SMILES

O=C(C1=CC([N+]([O-])=O)=C(O)C(OC)=C1)C2=CC=C(C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3-O-Methyltolcapone Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-Methyltolcapone134612-80-9Ro 40-7591COMTCatechol-O-methyltransferaseMetaboliteTolcaponeblood-brainbarrierParkinson'sdiseaseInhibitorinhibitorinhibit

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