3-Phenyltoxoflavin

Name: 3-Phenyltoxoflavin
Brand: MedChemExpress
SKU: HY-125759
Rating: 4.5 (1 reviews)

Cat. No.: HY-125759 Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a K_d of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity.

For research use only. We do not sell to patients.

3-Phenyltoxoflavin Chemical Structure

CAS No. : 32502-63-9

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 165	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 165	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

Description

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a K_d of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity^[1]^[2].

IC₅₀ & Target^[1]

HSP90

585 nM (Kd)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.1 μM Compound: 4a	Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay	[PMID: 31784197]
HepG2	IC₅₀	0.87 μM Compound: 4a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay	[PMID: 31784197]

In Vitro

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC₅₀ of 690 nM^[1].
3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.26

Formula

C₁₃H₁₁N₅O₂

CAS No.

32502-63-9

Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(C1=NC(C2=CC=CC=C2)=NN(C)C1=N3)N(C)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 7.14 mg/mL (26.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7139 mL	18.5694 mL	37.1388 mL
5 mM	0.7428 mL	3.7139 mL	7.4278 mL
10 mM	0.3714 mL	1.8569 mL	3.7139 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (273 KB) SDS (480 KB)

COA (250 KB) HNMR (224 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54. [Content Brief]

[2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7139 mL	18.5694 mL	37.1388 mL	92.8471 mL
	5 mM	0.7428 mL	3.7139 mL	7.4278 mL	18.5694 mL
	10 mM	0.3714 mL	1.8569 mL	3.7139 mL	9.2847 mL
	15 mM	0.2476 mL	1.2380 mL	2.4759 mL	6.1898 mL
	20 mM	0.1857 mL	0.9285 mL	1.8569 mL	4.6424 mL
	25 mM	0.1486 mL	0.7428 mL	1.4856 mL	3.7139 mL