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  4. 3'-Sialyllactose sodium

3'-Sialyllactose sodium  (Synonyms: 3'-SL sodium)

Cat. No.: HY-108065A Purity: ≥98.0%
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3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

For research use only. We do not sell to patients.

3'-Sialyllactose sodium Chemical Structure

3'-Sialyllactose sodium Chemical Structure

CAS No. : 128596-80-5

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10 mg USD 70 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 3'-Sialyllactose sodium:

3'-Sialyllactose sodium Related Antibodies

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Description

3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3].

In Vitro

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].
3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3'-Sialyllactose sodium Related Antibodies

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 0, 50, 100 and 250 μM
Incubation Time: 24-36 hours
Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.
In Vivo

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1]
Dosage: 10, 50 and 100 mg/kg
Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.
Molecular Weight

655.53

Formula

C23H38NNaO19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)O
Structure Classification
Initial Source

human milk
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (381.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5255 mL 7.6274 mL 15.2548 mL
5 mM 0.3051 mL 1.5255 mL 3.0510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (261 KB) HNMR (144 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5255 mL 7.6274 mL 15.2548 mL 38.1371 mL
5 mM 0.3051 mL 1.5255 mL 3.0510 mL 7.6274 mL
10 mM 0.1525 mL 0.7627 mL 1.5255 mL 3.8137 mL
15 mM 0.1017 mL 0.5085 mL 1.0170 mL 2.5425 mL
20 mM 0.0763 mL 0.3814 mL 0.7627 mL 1.9069 mL
25 mM 0.0610 mL 0.3051 mL 0.6102 mL 1.5255 mL
30 mM 0.0508 mL 0.2542 mL 0.5085 mL 1.2712 mL
40 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9534 mL
50 mM 0.0305 mL 0.1525 mL 0.3051 mL 0.7627 mL
60 mM 0.0254 mL 0.1271 mL 0.2542 mL 0.6356 mL
80 mM 0.0191 mL 0.0953 mL 0.1907 mL 0.4767 mL
100 mM 0.0153 mL 0.0763 mL 0.1525 mL 0.3814 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3'-Sialyllactose sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Sialyllactose128596-80-53'-SLNF-κBNuclear factor-κBNuclear factor-kappaBpolysaccharideprebiotichomeostasisinflammationimmuneCol2a1osteoarthritismiceInhibitorinhibitorinhibit

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