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  4. 4-Trifluoromethylsalicylic acid

4-Trifluoromethylsalicylic acid  (Synonyms: Desacetyl triflusal)

Cat. No.: HY-W014632 Purity: 99.87%
COA Handling Instructions

Molarity Calculator

4-Trifluoromethylsalicylic acid (Desacetyl triflusal) is a platelet aggregation inhibitor.

For research use only. We do not sell to patients.

4-Trifluoromethylsalicylic acid Chemical Structure

4-Trifluoromethylsalicylic acid Chemical Structure

CAS No. : 328-90-5

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Trifluoromethylsalicylic acid:

4-Trifluoromethylsalicylic acid Related Antibodies

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Description

4-Trifluoromethylsalicylic acid (Desacetyl triflusal) is a platelet aggregation inhibitor[1].

Molecular Weight

206.12

Formula

C8H5F3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC(O)=C(C(O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (485.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8515 mL 24.2577 mL 48.5154 mL
5 mM 0.9703 mL 4.8515 mL 9.7031 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.13 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.13 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.87%

COA (247 KB) HNMR (128 KB) RP-HPLC (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8515 mL 24.2577 mL 48.5154 mL 121.2886 mL
5 mM 0.9703 mL 4.8515 mL 9.7031 mL 24.2577 mL
10 mM 0.4852 mL 2.4258 mL 4.8515 mL 12.1289 mL
15 mM 0.3234 mL 1.6172 mL 3.2344 mL 8.0859 mL
20 mM 0.2426 mL 1.2129 mL 2.4258 mL 6.0644 mL
25 mM 0.1941 mL 0.9703 mL 1.9406 mL 4.8515 mL
30 mM 0.1617 mL 0.8086 mL 1.6172 mL 4.0430 mL
40 mM 0.1213 mL 0.6064 mL 1.2129 mL 3.0322 mL
50 mM 0.0970 mL 0.4852 mL 0.9703 mL 2.4258 mL
60 mM 0.0809 mL 0.4043 mL 0.8086 mL 2.0215 mL
80 mM 0.0606 mL 0.3032 mL 0.6064 mL 1.5161 mL
100 mM 0.0485 mL 0.2426 mL 0.4852 mL 1.2129 mL
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4-Trifluoromethylsalicylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Trifluoromethylsalicylic acid328-90-5Desacetyl triflusalOthersInhibitorinhibitorinhibit

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