5-Methyluridine-d₄

Cat. No.: HY-W009444S: FAQs
Data Sheet Handling Instructions

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5-Methyluridine-d₄ is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].

For research use only. We do not sell to patients.

5-Methyluridine-d<sub>4</sub> Chemical Structure

5-Methyluridine-d₄ Chemical Structure

CAS No. : 82845-85-0

Size	Price	Stock
1 mg	USD 380	Ask For Quote & Lead Time
5 mg	USD 750	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of 5-Methyluridine-d₄:

5-Methyluridine In-stock

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Biological Activity
Purity & Documentation
References
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Description

5-Methyluridine-d₄ is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

262.25

Formula

C₁₀H₁₀D₄N₂O₆

CAS No.

82845-85-0

Unlabeled CAS

1463-10-1

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C(C([2H])([2H])[2H])=C2[2H])=O)=O)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (381.32 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8132 mL	19.0658 mL	38.1316 mL
5 mM	0.7626 mL	3.8132 mL	7.6263 mL
10 mM	0.3813 mL	1.9066 mL	3.8132 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8132 mL	19.0658 mL	38.1316 mL	95.3289 mL
	5 mM	0.7626 mL	3.8132 mL	7.6263 mL	19.0658 mL
	10 mM	0.3813 mL	1.9066 mL	3.8132 mL	9.5329 mL
	15 mM	0.2542 mL	1.2711 mL	2.5421 mL	6.3553 mL
	20 mM	0.1907 mL	0.9533 mL	1.9066 mL	4.7664 mL
	25 mM	0.1525 mL	0.7626 mL	1.5253 mL	3.8132 mL
	30 mM	0.1271 mL	0.6355 mL	1.2711 mL	3.1776 mL
	40 mM	0.0953 mL	0.4766 mL	0.9533 mL	2.3832 mL
	50 mM	0.0763 mL	0.3813 mL	0.7626 mL	1.9066 mL
	60 mM	0.0636 mL	0.3178 mL	0.6355 mL	1.5888 mL
	80 mM	0.0477 mL	0.2383 mL	0.4766 mL	1.1916 mL
	100 mM	0.0381 mL	0.1907 mL	0.3813 mL	0.9533 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.