5-Pentadecylresorcinol (Synonyms: Adipostatin A)

Name: 5-Pentadecylresorcinol
Brand: MedChemExpress
SKU: HY-116934
Rating: 4.5 (1 reviews)

Cat. No.: HY-116934 Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions

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5-Pentadecylresorcinol (Adipostatin A) is a glycerol-3-phosphate dehydrogenase (GPDH) inhibitor with an IC₅₀ of 4.1 µM. Adipostatin A shows good larvicidal activity against Aedes aegypti.

For research use only. We do not sell to patients.

5-Pentadecylresorcinol Chemical Structure

CAS No. : 3158-56-3

Size	Price	Stock	Quantity
1 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Pentadecylresorcinol:

5-Pentadecylresorcinol (Standard) Get quote

1 Publications Citing Use of MCE 5-Pentadecylresorcinol

•Mol Cell. 2024 Jan 17:S1097-2765(24)00003-0. [Abstract]

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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.31 μM Compound: 9	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 17125236]
A549	IC₅₀	1.43 μM Compound: 9	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 17125236]
A549	ED₅₀	2.37 μg/mL Compound: 6	Cytotoxicity against human A549 cells after 7 days Cytotoxicity against human A549 cells after 7 days	[PMID: 8201311]
Bel-7402	IC₅₀	1.93 μM Compound: 9	Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay	[PMID: 17125236]
BGC-823	IC₅₀	1.74 μM Compound: 9	Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay	[PMID: 17125236]
HCT-8	IC₅₀	1.48 μM Compound: 9	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 17125236]
HT-29	ED₅₀	3.25 μg/mL Compound: 6	Cytotoxicity against human HT-29 cells after 7 days Cytotoxicity against human HT-29 cells after 7 days	[PMID: 8201311]
MCF7	ED₅₀	2.41 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells after 7 days Cytotoxicity against human MCF7 cells after 7 days	[PMID: 8201311]

In Vitro

5-Pentadecylresorcinol (Adipostatin A) prevents triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

320.51

Formula

C₂₁H₃₆O₂

CAS No.

3158-56-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC(O)=CC(CCCCCCCCCCCCCCC)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (156.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1200 mL	15.6001 mL	31.2003 mL
5 mM	0.6240 mL	3.1200 mL	6.2401 mL
10 mM	0.3120 mL	1.5600 mL	3.1200 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 1.25 mg/mL (3.90 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.90 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.30%

Select Batch:

Data Sheet (270 KB) SDS (392 KB)

COA (239 KB)

Handling Instructions (2659 KB)

References

[1]. Tsuge, et al. Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase. J Antibiot (Tokyo). 1992 Jun;45(6):886-91. [Content Brief]

[2]. Micheline Soares Costa Oliveira, et al. Antioxidant, larvicidal and antiacetylcholinesterase activities of cashew nut shell liquid constituents. Acta Trop. 2011 Mar;117(3):165-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1200 mL	15.6001 mL	31.2003 mL	78.0007 mL
	5 mM	0.6240 mL	3.1200 mL	6.2401 mL	15.6001 mL
	10 mM	0.3120 mL	1.5600 mL	3.1200 mL	7.8001 mL
	15 mM	0.2080 mL	1.0400 mL	2.0800 mL	5.2000 mL
	20 mM	0.1560 mL	0.7800 mL	1.5600 mL	3.9000 mL
	25 mM	0.1248 mL	0.6240 mL	1.2480 mL	3.1200 mL
	30 mM	0.1040 mL	0.5200 mL	1.0400 mL	2.6000 mL
	40 mM	0.0780 mL	0.3900 mL	0.7800 mL	1.9500 mL
	50 mM	0.0624 mL	0.3120 mL	0.6240 mL	1.5600 mL
	60 mM	0.0520 mL	0.2600 mL	0.5200 mL	1.3000 mL
	80 mM	0.0390 mL	0.1950 mL	0.3900 mL	0.9750 mL
	100 mM	0.0312 mL	0.1560 mL	0.3120 mL	0.7800 mL

5-Pentadecylresorcinol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Pentadecylresorcinol3158-56-3Adipostatin AOthersglycerol-3-phosphate dehydrogenase (GPDH) inhibitorlarvicidal activityInhibitorinhibitorinhibit

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5-Pentadecylresorcinol (Synonyms: Adipostatin A)

Customer Review

Other Forms of 5-Pentadecylresorcinol:

5-Pentadecylresorcinol Related Antibodies

1 Publications Citing Use of MCE 5-Pentadecylresorcinol

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

5-Pentadecylresorcinol Related Antibodies

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Complete Stock Solution Preparation Table

5-Pentadecylresorcinol Related Classifications

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