Locked nucleic acid 1

Cat. No.: HY-111807: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

For research use only. We do not sell to patients.

Locked nucleic acid 1 Chemical Structure

CAS No. : 206055-71-2

Size	Price	Stock
50 mg	USD 50	Ask For Quote & Lead Time
100 mg	USD 90	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Description

Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

Molecular Weight

572.61

Formula

C₃₂H₃₂N₂O₈

CAS No.

206055-71-2

SMILES

O[C@H]1[C@@H](OC2)[C@H](N3C(NC(C(C)=C3)=O)=O)O[C@]12COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (436.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7464 mL	8.7319 mL	17.4639 mL
5 mM	0.3493 mL	1.7464 mL	3.4928 mL
10 mM	0.1746 mL	0.8732 mL	1.7464 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (10.91 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 6.25 mg/mL (10.91 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7464 mL	8.7319 mL	17.4639 mL	43.6597 mL
	5 mM	0.3493 mL	1.7464 mL	3.4928 mL	8.7319 mL
	10 mM	0.1746 mL	0.8732 mL	1.7464 mL	4.3660 mL
	15 mM	0.1164 mL	0.5821 mL	1.1643 mL	2.9106 mL
	20 mM	0.0873 mL	0.4366 mL	0.8732 mL	2.1830 mL
	25 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.7464 mL
	30 mM	0.0582 mL	0.2911 mL	0.5821 mL	1.4553 mL
	40 mM	0.0437 mL	0.2183 mL	0.4366 mL	1.0915 mL
	50 mM	0.0349 mL	0.1746 mL	0.3493 mL	0.8732 mL
	60 mM	0.0291 mL	0.1455 mL	0.2911 mL	0.7277 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5457 mL
	100 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4366 mL