2. Metabolic Enzyme/Protease
  3. PAI-1
  4. 6-Aminocaproic acid

6-Aminocaproic acid  (Synonyms: EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic acid)

Cat. No.: HY-B0236 Purity: ≥98.0%
SDS COA Handling Instructions

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6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.

For research use only. We do not sell to patients.

6-Aminocaproic acid Chemical Structure

6-Aminocaproic acid Chemical Structure

CAS No. : 60-32-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
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100 mg USD 80 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of 6-Aminocaproic acid:

6-Aminocaproic acid Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

In Vitro

6-Aminocaproic acid (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2].
6-Aminocaproic acid can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Aminocaproic acid Related Antibodies
In Vivo

6-Aminocaproic acid (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3].
6-Aminocaproic acid (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

131.17

Formula

C6H13NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCN
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (381.18 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6237 mL 38.1185 mL 76.2369 mL
5 mM 1.5247 mL 7.6237 mL 15.2474 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (190.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.77%

SDS (393 KB)

COA (241 KB) HNMR (122 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.6237 mL 38.1185 mL 76.2369 mL 190.5924 mL
5 mM 1.5247 mL 7.6237 mL 15.2474 mL 38.1185 mL
10 mM 0.7624 mL 3.8118 mL 7.6237 mL 19.0592 mL
15 mM 0.5082 mL 2.5412 mL 5.0825 mL 12.7062 mL
20 mM 0.3812 mL 1.9059 mL 3.8118 mL 9.5296 mL
25 mM 0.3049 mL 1.5247 mL 3.0495 mL 7.6237 mL
30 mM 0.2541 mL 1.2706 mL 2.5412 mL 6.3531 mL
40 mM 0.1906 mL 0.9530 mL 1.9059 mL 4.7648 mL
50 mM 0.1525 mL 0.7624 mL 1.5247 mL 3.8118 mL
60 mM 0.1271 mL 0.6353 mL 1.2706 mL 3.1765 mL
80 mM 0.0953 mL 0.4765 mL 0.9530 mL 2.3824 mL
100 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9059 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6-Aminocaproic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Aminocaproic acid60-32-2EACA Epsilon-Amino-n-caproic Acid 6-Aminohexanoic acidPAI-1Plasminogen activator inhibitor-1plasminplasminogenantifibrinolyticclotlysisfibrinolysisbleedingInhibitorinhibitorinhibit

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