2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. 6-Deoxyjacareubin

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

6-Deoxyjacareubin Chemical Structure

6-Deoxyjacareubin Chemical Structure

CAS No. : 16265-56-8

Size Price Stock Quantity
1 mg USD 500 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
5 mg USD 1255 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
10 mg   Get quote  
50 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

6-Deoxyjacareubin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
26 μM
Compound: 11
Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay
Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay
[PMID: 29475587]
HL-60 IC50
2.7 μM
Compound: 11
Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay
Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay
[PMID: 29475587]
NIH3T3 CC50
25.3 μM
Compound: 11
Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by CCK8 assay
Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by CCK8 assay
[PMID: 29475587]
In Vitro

6-deoxyjacareubin inhibits cytotoxicity induced by sealed chamber hypoxia (1 % O2) and chemically induced hypoxia (CoCl2) in HEK293T cells and other types of cell lines such as HT1080 (human sarcoma cell line), Neuro2a (mouse neuroblastoma cell line), and MO3.13 (human oligodendrocytic cell line)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Deoxyjacareubin Related Antibodies
In Vivo

6-Deoxyjacareubin (5 mg/kg，腹腔注射，每7天一次，连用1个月) 减轻家族性 ALS 模型小鼠的运动神经元丢失[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SOD1G93A mice (eight weeks)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneally (i.p.), every seven days for 1 month
Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
Molecular Weight

310.30

Formula

C18H14O5
CAS No.
SMILES

O=C1C2=C(OC3=C1C=CC=C3O)C=C4C(C=CC(C)(C)O4)=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

6-Deoxyjacareubin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Deoxyjacareubin16265-56-8Reactive Oxygen SpeciesAmyotrophic lateral sclerosisHEK293T cellslocomotor dysfunctionnon-apoptotic cell deathHT1080MO3.13Neuro2aneurodegenerationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
6-Deoxyjacareubin
Cat. No.:
HY-N2707
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.