2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Velsecorat

Velsecorat  (Synonyms: AZD7594; AZ13189620)

Cat. No.: HY-111453 Purity: 99.43%
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AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.

For research use only. We do not sell to patients.

Velsecorat Chemical Structure

Velsecorat Chemical Structure

CAS No. : 1196509-60-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 214 In-stock
Solution
10 mM * 1 mL in DMSO USD 214 In-stock
Solid
5 mg USD 160 In-stock
10 mg USD 220 In-stock
25 mg USD 490 In-stock
50 mg USD 790 In-stock
100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Velsecorat Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Velsecorat

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.

IC50 & Target

IC50: 0.9 nM (Glucocorticoid receptor)[1]
In Vitro

AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Velsecorat Related Antibodies
In Vivo

AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

606.62

Formula

C32H32F2N4O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H]1COCC1)C2=CC=CC(N3N=CC4=C3C=CC(O[C@H](C5=CC=C(OCCO6)C6=C5)[C@@H](NC(C(F)(F)C)=O)C)=C4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (137.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6485 mL 8.2424 mL 16.4848 mL
5 mM 0.3297 mL 1.6485 mL 3.2970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Kinase Assay
[1]

Androgen receptor (AR) binding is measured in a fluorescence polarization ligand displacement assay using commercially available reagents, including recombinant rat AR ligand binding domain tagged with His and GST, Fluormone labelled AL Green ligand, DTT and AR Green assay buffer (containing protein stabilizing agents and glycerol, pH 7.5). Test compounds (AZD7594, etc.) and controls in 100% DMSO are added to 384-well plates in 0.2 μL. AR-LBD and Fluomone AL Green in AR Green assay buffer are added to 12.5 nM and 0.5 nM in a final volume of 15 μL. Plates are incubated in the dark at room temperature for 4-6 hours before fluorescence polarization is measured (excitation 485 nm, emission 530 nm). The shift in polarization value in the presence of test compounds (AZD7594, etc.) is used to determine relative affinity of test compounds for AR. The minimum and maximum values are determined in the in the presence of testosterone (1.3 μM) and in the absence of test compound. The molar concentration of compound producing 50% binding (IC50) of AR is mesured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6485 mL 8.2424 mL 16.4848 mL 41.2120 mL
5 mM 0.3297 mL 1.6485 mL 3.2970 mL 8.2424 mL
10 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1212 mL
15 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7475 mL
20 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
25 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6485 mL
30 mM 0.0549 mL 0.2747 mL 0.5495 mL 1.3737 mL
40 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0303 mL
50 mM 0.0330 mL 0.1648 mL 0.3297 mL 0.8242 mL
60 mM 0.0275 mL 0.1374 mL 0.2747 mL 0.6869 mL
80 mM 0.0206 mL 0.1030 mL 0.2061 mL 0.5151 mL
100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.4121 mL
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Velsecorat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Velsecorat1196509-60-0AZD7594 AZ13189620AZD 7594AZD-7594AZ13189620AZ 13189620AZ-13189620Glucocorticoid ReceptorInhibitorinhibitorinhibit

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