Alcaftadine (Synonyms: R89674)

Cat. No.: HY-17039 Purity: 99.43%: FAQs
Data Sheet SDS COA Handling Instructions

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Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects.

For research use only. We do not sell to patients.

Alcaftadine Chemical Structure

CAS No. : 147084-10-4

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 73	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 73	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 42	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 211	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Alcaftadine:

Alcaftadine-D3 Get quote
Alcaftadine (Standard) Get quote

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View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₁ Receptor

H₂ Receptor

Clinical Trial

Molecular Weight

307.39

Formula

C₁₉H₂₁N₃O

CAS No.

147084-10-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 40 mg/mL (130.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2532 mL	16.2660 mL	32.5320 mL
5 mM	0.6506 mL	3.2532 mL	6.5064 mL
10 mM	0.3253 mL	1.6266 mL	3.2532 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.43%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (255 KB) LCMS (271 KB)

Handling Instructions (2659 KB)

References

[1]. Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90. [Content Brief]

[2]. Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2532 mL	16.2660 mL	32.5320 mL	81.3299 mL
	5 mM	0.6506 mL	3.2532 mL	6.5064 mL	16.2660 mL
	10 mM	0.3253 mL	1.6266 mL	3.2532 mL	8.1330 mL
	15 mM	0.2169 mL	1.0844 mL	2.1688 mL	5.4220 mL
	20 mM	0.1627 mL	0.8133 mL	1.6266 mL	4.0665 mL
	25 mM	0.1301 mL	0.6506 mL	1.3013 mL	3.2532 mL
	30 mM	0.1084 mL	0.5422 mL	1.0844 mL	2.7110 mL
	40 mM	0.0813 mL	0.4066 mL	0.8133 mL	2.0332 mL
	50 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6266 mL
	60 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL
	80 mM	0.0407 mL	0.2033 mL	0.4066 mL	1.0166 mL
	100 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL

Alcaftadine Related Classifications

Inflammation/Immunology Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alcaftadine147084-10-4R89674R 89674R-89674Histamine ReceptorInhibitorinhibitorinhibit

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