2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Bethanechol chloride

Bethanechol chloride  (Synonyms: Carbamyl-β-methylcholine chloride)

Cat. No.: HY-B0406A Purity: 98.15%
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Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

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Bethanechol chloride Chemical Structure

Bethanechol chloride Chemical Structure

CAS No. : 590-63-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Bethanechol chloride:

Bethanechol chloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bethanechol chloride

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

IC50 & Target

mAChR1

 

mAChR3

 

mAChR4

 

mAChR5

 

In Vitro

Bethanechol chloride (0.3-300 μM) significantly reduces ileal pacemaker potentials[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bethanechol chloride Related Antibodies
In Vivo

Bethanechol (2-12 mg/kg; i.p.) induces drinking and increases urine output of rats in a dose-dependent fashion[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4]
Dosage: 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
Administration: Intraperitoneal injection
Result: Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).
Clinical Trial
Molecular Weight

196.68

Formula

C7H17ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(OC(N)=O)C[N+](C)(C)C.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (254.22 mM)

DMSO : 11.11 mg/mL (56.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0844 mL 25.4220 mL 50.8440 mL
5 mM 1.0169 mL 5.0844 mL 10.1688 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (508.44 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.0844 mL 25.4220 mL 50.8440 mL 127.1100 mL
5 mM 1.0169 mL 5.0844 mL 10.1688 mL 25.4220 mL
10 mM 0.5084 mL 2.5422 mL 5.0844 mL 12.7110 mL
15 mM 0.3390 mL 1.6948 mL 3.3896 mL 8.4740 mL
20 mM 0.2542 mL 1.2711 mL 2.5422 mL 6.3555 mL
25 mM 0.2034 mL 1.0169 mL 2.0338 mL 5.0844 mL
30 mM 0.1695 mL 0.8474 mL 1.6948 mL 4.2370 mL
40 mM 0.1271 mL 0.6356 mL 1.2711 mL 3.1778 mL
50 mM 0.1017 mL 0.5084 mL 1.0169 mL 2.5422 mL
H2O 60 mM 0.0847 mL 0.4237 mL 0.8474 mL 2.1185 mL
80 mM 0.0636 mL 0.3178 mL 0.6356 mL 1.5889 mL
100 mM 0.0508 mL 0.2542 mL 0.5084 mL 1.2711 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bethanechol chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bethanechol590-63-6Carbamyl-β-methylcholinemAChRMuscarinic acetylcholine receptorparasympathomimeticparasympatheticreceptorspostoperativeurinaryretentionpostpartumurinary ,retentionoverflowincontinenceInhibitorinhibitorinhibit

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