2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Bevenopran

Bevenopran  (Synonyms: CB-5945; ADL-5945)

Cat. No.: HY-100122 Purity: 99.82%
COA Handling Instructions

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Bevenopran is a peripheral μ-opioid receptor antagonist.

For research use only. We do not sell to patients.

Bevenopran Chemical Structure

Bevenopran Chemical Structure

CAS No. : 676500-67-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 418 In-stock
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 380 In-stock
10 mg USD 580 In-stock
25 mg USD 930 In-stock
50 mg USD 1270 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Bevenopran Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bevenopran

IF

    Bevenopran purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023, 158: 114141.

    Calcium influx assay. (+)-MML1017 activates of μOR to increases cytosolic Ca2+ concentration, but the agonism of (+)-MML1017 is blocked by Bevenopran (10 mM; 30 min) in hMOR-chem5 cells.

    View All Opioid Receptor Isoform Specific Products:

    View All Isoforms
    μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bevenopran is a peripheral μ-opioid receptor antagonist[1][2].

    IC50 & Target

    μ Opioid Receptor/MOR

     

    In Vivo

    Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    386.44

    Formula

    C20H26N4O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=NC=C(OC2=CC=C(CNCCC3CCOCC3)C=C2OC)N=C1)N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (323.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5877 mL 12.9386 mL 25.8772 mL
    5 mM 0.5175 mL 2.5877 mL 5.1754 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (5.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5877 mL 12.9386 mL 25.8772 mL 64.6931 mL
    5 mM 0.5175 mL 2.5877 mL 5.1754 mL 12.9386 mL
    10 mM 0.2588 mL 1.2939 mL 2.5877 mL 6.4693 mL
    15 mM 0.1725 mL 0.8626 mL 1.7251 mL 4.3129 mL
    20 mM 0.1294 mL 0.6469 mL 1.2939 mL 3.2347 mL
    25 mM 0.1035 mL 0.5175 mL 1.0351 mL 2.5877 mL
    30 mM 0.0863 mL 0.4313 mL 0.8626 mL 2.1564 mL
    40 mM 0.0647 mL 0.3235 mL 0.6469 mL 1.6173 mL
    50 mM 0.0518 mL 0.2588 mL 0.5175 mL 1.2939 mL
    60 mM 0.0431 mL 0.2156 mL 0.4313 mL 1.0782 mL
    80 mM 0.0323 mL 0.1617 mL 0.3235 mL 0.8087 mL
    100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6469 mL
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    Bevenopran Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bevenopran676500-67-7CB-5945 ADL-5945CB5945CB 5945ADL5945ADL 5945ADL-5945Opioid ReceptorInhibitorinhibitorinhibit

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