Biperiden (Synonyms: KL 373)

Cat. No.: HY-13204A Purity: 99.74%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.

For research use only. We do not sell to patients.

Biperiden Chemical Structure

CAS No. : 514-65-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 143	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 143	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Biperiden:

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration:	29.6 μg/mL
Incubation Time:	72 hours
Result:	Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.

In Vivo

Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1].
Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; everyday; 3 weeks
Result:	Tumor size reduced by 83%.

Animal Model:	Male Wistar rats (200-250 g)^[2]
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection; every 8 hours; 10 days
Result:	Reduced late seizures by about three times with no affecting emotional memory damage.

Clinical Trial

Molecular Weight

311.46

Formula

C₂₁H₂₉NO

CAS No.

514-65-8

Appearance

Solid

Color

White to off-white

SMILES

OC([C@H]1C[C@@H]2C=C[C@H]1C2)(CCN3CCCCC3)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (160.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.82 mg/mL (5.84 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2107 mL	16.0534 mL	32.1069 mL
5 mM	0.6421 mL	3.2107 mL	6.4214 mL
10 mM	0.3211 mL	1.6053 mL	3.2107 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.74%

Select Batch:

Data Sheet (277 KB) SDS (392 KB)

COA (252 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Leonie Konczalla，et al. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630. [Content Brief]

[2]. Simone Bittencourt, et al. Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy. Epilepsy Res. 2017 Dec;138:88-97. doi: 10.1016/j.eplepsyres.2017.10.019. Epub 2017 Oct 29. [Content Brief]

[3]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10) [Content Brief]

[4]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8) [Content Brief]

[5]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.2107 mL	16.0534 mL	32.1069 mL	80.2671 mL
H₂O / DMSO	5 mM	0.6421 mL	3.2107 mL	6.4214 mL	16.0534 mL
DMSO	10 mM	0.3211 mL	1.6053 mL	3.2107 mL	8.0267 mL
	15 mM	0.2140 mL	1.0702 mL	2.1405 mL	5.3511 mL
	20 mM	0.1605 mL	0.8027 mL	1.6053 mL	4.0134 mL
	25 mM	0.1284 mL	0.6421 mL	1.2843 mL	3.2107 mL
	30 mM	0.1070 mL	0.5351 mL	1.0702 mL	2.6756 mL
	40 mM	0.0803 mL	0.4013 mL	0.8027 mL	2.0067 mL
	50 mM	0.0642 mL	0.3211 mL	0.6421 mL	1.6053 mL
	60 mM	0.0535 mL	0.2676 mL	0.5351 mL	1.3378 mL
	80 mM	0.0401 mL	0.2007 mL	0.4013 mL	1.0033 mL
	100 mM	0.0321 mL	0.1605 mL	0.3211 mL	0.8027 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Biperiden Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biperiden514-65-8KL 373KL373KL-373mAChRMuscarinic acetylcholine receptorMuscarinic receptor antagonistParkinson's diseaseAnticholinergicInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks