2. Metabolic Enzyme/Protease
  3. NAMPT
  4. CB30865

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range).

For research use only. We do not sell to patients.

CB30865 Chemical Structure

CB30865 Chemical Structure

CAS No. : 206275-15-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 284 In-stock
Solution
10 mM * 1 mL in DMSO USD 284 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 360 In-stock
50 mg USD 890 In-stock
100 mg USD 1300 In-stock
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CB30865 Related Antibodies

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Description

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2].

In Vitro

CB30865 exhibits cytotoxicity due to NAD reduction via Nampt inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB30865 Related Antibodies
Molecular Weight

516.39

Formula

C26H22BrN5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(N=C(C)NC4=O)C=C3Br)CC#C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9365 mL 9.6826 mL 19.3652 mL
5 mM 0.3873 mL 1.9365 mL 3.8730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9365 mL 9.6826 mL 19.3652 mL 48.4130 mL
5 mM 0.3873 mL 1.9365 mL 3.8730 mL 9.6826 mL
10 mM 0.1937 mL 0.9683 mL 1.9365 mL 4.8413 mL
15 mM 0.1291 mL 0.6455 mL 1.2910 mL 3.2275 mL
20 mM 0.0968 mL 0.4841 mL 0.9683 mL 2.4207 mL
25 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.9365 mL
30 mM 0.0646 mL 0.3228 mL 0.6455 mL 1.6138 mL
40 mM 0.0484 mL 0.2421 mL 0.4841 mL 1.2103 mL
50 mM 0.0387 mL 0.1937 mL 0.3873 mL 0.9683 mL
60 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8069 mL
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CB30865 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB30865206275-15-2ZM 242421CB 30865CB-30865ZM242421ZM-242421NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorcytotoxic NamptNADbiosyntheticpathwaycellcyclearrestInhibitorinhibitorinhibit

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