CL-387785 (Synonyms: EKI-785; WAY-EKI 785)

Cat. No.: HY-10325 Purity: 98.05%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC₅₀ of 370 pM.

For research use only. We do not sell to patients.

CL-387785 Chemical Structure

CAS No. : 194423-06-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 77	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 77	In-stock	Estimated Time of Arrival: December 31
Solid
2 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE CL-387785

•Int J Oncol. 2023 Jul 9;63(1):84. [Abstract]

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Biological Activity
Purity & Documentation
References
Customer Review

Description

CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC₅₀ of 370 pM.

IC₅₀ & Target^[1]

EGFR

370 pM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.079 μM Compound: 1	Inhibition of cell growth of human epidermoid carcinoma xenograft (A431) model using cell based assay Inhibition of cell growth of human epidermoid carcinoma xenograft (A431) model using cell based assay	[PMID: 11495584]
SK-BR-3	IC₅₀	0.017 μM Compound: 1	Inhibition of cell growth of SKBr3 cell lines using cell-based assay Inhibition of cell growth of SKBr3 cell lines using cell-based assay	[PMID: 11495584]
SW-620	IC₅₀	1.5 μM Compound: 1	Inhibition of cell growth of SW620 cell lines using cell-based assay Inhibition of cell growth of SW620 cell lines using cell-based assay	[PMID: 11495584]

Molecular Weight

381.23

Formula

C₁₈H₁₃BrN₄O

CAS No.

194423-06-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)C#CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 13.67 mg/mL (35.86 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6231 mL	13.1154 mL	26.2309 mL
5 mM	0.5246 mL	2.6231 mL	5.2462 mL
10 mM	0.2623 mL	1.3115 mL	2.6231 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.05%

Select Batch:

Data Sheet (272 KB) SDS (583 KB)

COA (247 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Discafani CM, et al. Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785). Biochem Pharmacol. 1999 Apr 15;57(8):917-25. [Content Brief]

[2]. Sweeney WE, et al. Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int. 2000 Jan;57(1):33-40. [Content Brief]

[3]. Greulich H, et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005 Nov;2(11):e313. [Content Brief]

[4]. Kobayashi S, et al. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res. 2005 Aug 15;65(16):7096-101. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6231 mL	13.1154 mL	26.2309 mL	65.5772 mL
	5 mM	0.5246 mL	2.6231 mL	5.2462 mL	13.1154 mL
	10 mM	0.2623 mL	1.3115 mL	2.6231 mL	6.5577 mL
	15 mM	0.1749 mL	0.8744 mL	1.7487 mL	4.3718 mL
	20 mM	0.1312 mL	0.6558 mL	1.3115 mL	3.2789 mL
	25 mM	0.1049 mL	0.5246 mL	1.0492 mL	2.6231 mL
	30 mM	0.0874 mL	0.4372 mL	0.8744 mL	2.1859 mL

CL-387785 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL-387785194423-06-8EKI-785 WAY-EKI 785CL387785CL 387785EKI785EKI 785EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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CL-387785 (Synonyms: EKI-785; WAY-EKI 785)

Customer Review

CL-387785 Related Antibodies

1 Publications Citing Use of MCE CL-387785

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All EGFR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

CL-387785 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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