Carbinoxamine maleate salt

Name: Carbinoxamine maleate salt
Brand: MedChemExpress
SKU: HY-B1589A
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1589A Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Carbinoxamine maleate salt is a histamine H1 receptor antagonist.

For research use only. We do not sell to patients.

Carbinoxamine maleate salt Chemical Structure

CAS No. : 3505-38-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 92	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 92	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 84	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 228	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Carbinoxamine maleate salt:

Carbinoxamine-d₆ maleate Get quote
(±)-Carbinoxamine Get quote
Carbinoxamine maleate salt (Standard) Get quote

1 Publications Citing Use of MCE Carbinoxamine maleate salt

•Dis Model Mech. 2023 Mar 2;dmm.049769. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Carbinoxamine maleate salt is a histamine H1 receptor antagonist.

IC₅₀ & Target

histamine H1 receptor^[1]

Molecular Weight

406.86

Formula

C₂₀H₂₃ClN₂O₅

CAS No.

3505-38-2

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C(C2=NC=CC=C2)OCCN(C)C)C=C1.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (245.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (122.89 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4578 mL	12.2892 mL	24.5785 mL
5 mM	0.4916 mL	2.4578 mL	4.9157 mL
10 mM	0.2458 mL	1.2289 mL	2.4578 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (245.78 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (277 KB) SDS (420 KB)

COA (255 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Harikrishnan A, et al. The cooperative effect of Lewis pairs in the Friedel-Crafts hydroxyalkylation reaction: a simple and effective route for the synthesis of (±)-carbinoxamine. Org Biomol Chem. 2015 Mar 28;13(12):3633-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.4578 mL	12.2892 mL	24.5785 mL	61.4462 mL
	5 mM	0.4916 mL	2.4578 mL	4.9157 mL	12.2892 mL
	10 mM	0.2458 mL	1.2289 mL	2.4578 mL	6.1446 mL
	15 mM	0.1639 mL	0.8193 mL	1.6386 mL	4.0964 mL
	20 mM	0.1229 mL	0.6145 mL	1.2289 mL	3.0723 mL
	25 mM	0.0983 mL	0.4916 mL	0.9831 mL	2.4578 mL
	30 mM	0.0819 mL	0.4096 mL	0.8193 mL	2.0482 mL
	40 mM	0.0614 mL	0.3072 mL	0.6145 mL	1.5362 mL
	50 mM	0.0492 mL	0.2458 mL	0.4916 mL	1.2289 mL
	60 mM	0.0410 mL	0.2048 mL	0.4096 mL	1.0241 mL
	80 mM	0.0307 mL	0.1536 mL	0.3072 mL	0.7681 mL
	100 mM	0.0246 mL	0.1229 mL	0.2458 mL	0.6145 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.