Cefditoren Pivoxil (Synonyms: Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207)

Name: Cefditoren Pivoxil
Brand: MedChemExpress
SKU: HY-17452A
Rating: 4.5 (1 reviews)

Cat. No.: HY-17452A Purity: 99.29%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

For research use only. We do not sell to patients.

Cefditoren Pivoxil Chemical Structure

CAS No. : 117467-28-4

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 73	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 73	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 42	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 66	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 185	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 251	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 304	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefditoren Pivoxil:

Cefditoren-¹³C,d₃ Get quote
Cefditoren sodium Get quote
Cefditoren Pivoxil hydrochloride Get quote
Cefditoren Pivoxil (Standard) Get quote

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Metallo-β-lactamase

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

β-lactam

In Vitro

Cefditoren Pivoxil shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis^[1].

Organism	MIC50 (mg/L)	MIC90 (mg/L)	susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae (untyped)^a	0.015-0.25	0.12-1
PS	≤0.008-0.03	0.015-0.25	99-100
PI	0.06-0.5	0.25-0.5	94-100
PR	0.25-1	0.5-2	7-100
S. pyogenes	≤0.008-0.03	0.015-0.03	100
Staphylococcus aureus (MS)	0.12-0.5	0.5-1	50-100
Gram-negative organisms
Haemophilus	≤0.008-≤0.03	0.015-0.13
influenzae (untyped)^b
β-Lactamase +	≤0.008-0.03	0.015-0.06	100
β-Lactamase -	≤0.008-0.03	0.015-0.06	100
H. parainfluenzae^b	≤0.03	0.06
Moraxella	0.03-0.5	0.25-1	96
catarrhalis (untyped)^b
β-Lactamase +	≤0.03-0.25	0.12-0.5	100
β-Lactamase -	≤0.008-0.03	0.015-0.06	100

^a Including PS, PI and PR strains.
^b Including both β-lactamase-positive and -negative strains.
MIC_50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetics in mice^[1]:

Cefditoren (mg/kg)	C₀ (μg/ml)	t1/2 (h)	AUC_last (μg× h/ml)	T_last (h)
6.25	53.0	0.9	30.4	6
12.5	168.4	1.1	64.1	8
25	232.5	0.9	101.3	8
50	290.6	1.1	124.4	8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

620.72

Formula

C₂₅H₂₈N₆O₇S₃

CAS No.

117467-28-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (161.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6110 mL	8.0552 mL	16.1103 mL
5 mM	0.3222 mL	1.6110 mL	3.2221 mL
10 mM	0.1611 mL	0.8055 mL	1.6110 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.29%

Select Batch:

Data Sheet (281 KB) SDS (419 KB)

COA (254 KB) RP-HPLC (265 KB)

Handling Instructions (2659 KB)

References

[1]. Wellington K, et al. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 2004;64(22):2597-618. [Content Brief]

[2]. Cafini F, et al. Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model. PLoS One. 2010 Aug 10;5(8):e12041. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6110 mL	8.0552 mL	16.1103 mL	40.2758 mL
	5 mM	0.3222 mL	1.6110 mL	3.2221 mL	8.0552 mL
	10 mM	0.1611 mL	0.8055 mL	1.6110 mL	4.0276 mL
	15 mM	0.1074 mL	0.5370 mL	1.0740 mL	2.6851 mL
	20 mM	0.0806 mL	0.4028 mL	0.8055 mL	2.0138 mL
	25 mM	0.0644 mL	0.3222 mL	0.6444 mL	1.6110 mL
	30 mM	0.0537 mL	0.2685 mL	0.5370 mL	1.3425 mL
	40 mM	0.0403 mL	0.2014 mL	0.4028 mL	1.0069 mL
	50 mM	0.0322 mL	0.1611 mL	0.3222 mL	0.8055 mL
	60 mM	0.0269 mL	0.1343 mL	0.2685 mL	0.6713 mL
	80 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.5034 mL
	100 mM	0.0161 mL	0.0806 mL	0.1611 mL	0.4028 mL

Cefditoren Pivoxil Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cefditoren Pivoxil (Synonyms: Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207)

Customer Review

Other Forms of Cefditoren Pivoxil:

Cefditoren Pivoxil Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Beta-lactamase Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Cefditoren Pivoxil Related Antibodies

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Complete Stock Solution Preparation Table

Cefditoren Pivoxil Related Classifications

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