Cevipabulin fumarate (Synonyms: TTI-237 fumarate)

Name: Cevipabulin fumarate
Brand: MedChemExpress
SKU: HY-14949C
Rating: 5.0 (2 reviews)

Cat. No.: HY-14949C Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound and inhibits the binding of [³H]NSC 49842 to tubulin, with an IC₅₀ of 18-40 nM for cytotoxicity in human tumor cell line.

For research use only. We do not sell to patients.

Cevipabulin fumarate Chemical Structure

CAS No. : 849550-67-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1ML in DMSO ready for reconstitution	USD 112	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1ML in DMSO	USD 112	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 88	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 315	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 504	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 806	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Cevipabulin fumarate:

Cevipabulin In-stock

2 Publications Citing Use of MCE Cevipabulin fumarate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 18-40 nM (microtubule in human tumor cells)^[1].

In Vitro

Cevipabulin (0-50 nM, 72 hours) shows good activity (between 18 and 40 nM IC₅₀ values) on cell lines from ovarian, breast, prostate, and cervical tumors^[1].
Flow cytometry experiments reveal that, Cevipabulin (TTI-237) at low concentrations (20-40 nM) produces sub-G₁ nuclei and, at concentrations above 50 nM, it causes a strong G₂-M block^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Human cancer cell lines (SK-OV-3, MDA-MB-435, MDA-MB-468, LnCaP, and Hela cells).
Concentration:	0-50 nM
Incubation Time:	72 hours
Result:	The IC₅₀ values are 24±8 nM, 21±4 nM, 18±6 nM, 22±7 nM and 40 nM in SK-OV-3, MDA-MB-435, MDA-MB-468, LnCaP and Hela cells.

In Vivo

Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nu/nu female mice implanted s.c. in the flank with 1×10⁷ LoVo human colon adenocarcinoma cells^[1].
Dosage:	5, 10, 15, and 20 mg/kg
Administration:	I.V. injection every 4 days for 4 cycles.
Result:	The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.

Animal Model:	Athymic nu/nu female mice implanted s.c. in the flank with 1×10⁶ U87-MG human glioblastoma cells^[1].
Dosage:	25 mg/kg.
Administration:	P.O. or I.V. on days 0, 7, 14.
Result:	The compound was active by p.o. or i.v. administration against human tumor xenografts.

Clinical Trial

Molecular Weight

580.89

Formula

C₂₂H₂₂ClF₅N₆O₅

CAS No.

849550-67-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](C(F)(F)F)NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC=NN13.O=C(O)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (86.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.43 mg/mL (2.46 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7215 mL	8.6075 mL	17.2150 mL
5 mM	0.3443 mL	1.7215 mL	3.4430 mL
10 mM	0.1721 mL	0.8607 mL	1.7215 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (253 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. [Content Brief]

[2]. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both DB01229-like and Leurocristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.7215 mL	8.6075 mL	17.2150 mL	43.0374 mL
DMSO	5 mM	0.3443 mL	1.7215 mL	3.4430 mL	8.6075 mL
	10 mM	0.1721 mL	0.8607 mL	1.7215 mL	4.3037 mL
	15 mM	0.1148 mL	0.5738 mL	1.1477 mL	2.8692 mL
	20 mM	0.0861 mL	0.4304 mL	0.8607 mL	2.1519 mL
	25 mM	0.0689 mL	0.3443 mL	0.6886 mL	1.7215 mL
	30 mM	0.0574 mL	0.2869 mL	0.5738 mL	1.4346 mL
	40 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0759 mL
	50 mM	0.0344 mL	0.1721 mL	0.3443 mL	0.8607 mL
	60 mM	0.0287 mL	0.1435 mL	0.2869 mL	0.7173 mL
	80 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.5380 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cevipabulin fumarate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cevipabulin849550-67-0TTI-237TTI237TTI 237Microtubule/TubulinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Cevipabulin fumarate (Synonyms: TTI-237 fumarate)

Customer Review

Other Forms of Cevipabulin fumarate:

Cevipabulin fumarate Related Antibodies

2 Publications Citing Use of MCE Cevipabulin fumarate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Cevipabulin fumarate Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cevipabulin fumarate Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report