2. Anti-infection
  3. Bacterial Influenza Virus Parasite
  4. Chloroxylenol

Chloroxylenol  (Synonyms: p-chloro-m-xylenol)

Cat. No.: HY-B1414 Purity: 99.24%
SDS COA Handling Instructions

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Chloroxylenol is a broad-spectrum antibacterial agent that can be used to control bacteria, algae, fungi and viruses.

For research use only. We do not sell to patients.

Chloroxylenol Chemical Structure

Chloroxylenol Chemical Structure

CAS No. : 88-04-0

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chloroxylenol:

Chloroxylenol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Chloroxylenol is a broad-spectrum antibacterial agent that can be used to control bacteria, algae, fungi and viruses[1][2].

In Vitro

Chloroxylenol (0-250 μM, 24 or 48 h) inhibits the viability, proliferation, migration and invasion, and sphere formation, and induces apoptosis in HCT116 and SW480 cells by inhibiting Wnt/β-catenin signaling pathway[3].
Chloroxylenol (0-250 μM, 24 h) inhibits nuclear translocation of β-catenin in HCT116 and SW480 cells[3].
Chloroxylenol (0-250 μM, 7 days) inhibits the growth of CRC organoids[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chloroxylenol Related Antibodies

RT-PCR[3]

Cell Line: HCT116 and SW480 CRC cells
Concentration: 62.5-250 μM
Incubation Time: 24 h
Result: Decreased mRNA level Axin2, Survivin and LGR5, which indicates the antagonistic effect of Chloroxylenol on the Wnt/β-catenin signaling.
In Vivo

Chloroxylenol (5 mg/kg, i.p., on days 0, 2, 4, 6, 8 and 10) inhibits tumor growth in MC38 cell xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 cell xenograft model[3]
Dosage: 5 mg/kg
Administration: i.p., on days 0, 2, 4, 6, 8 and 10
Result: Reduced umor volume and weight.
Reduced tumor cell density (H&E).
Inhibited the expression of cancer stemness marker LGR5 in the tumor tissue, as well as the expression levels of LGR5 and SOX2.
Molecular Weight

156.61

Formula

C8H9ClO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C)=C(Cl)C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (638.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3853 mL 31.9264 mL 63.8529 mL
5 mM 1.2771 mL 6.3853 mL 12.7706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.24%

SDS (453 KB)

COA (247 KB) RP-HPLC (209 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3853 mL 31.9264 mL 63.8529 mL 159.6322 mL
5 mM 1.2771 mL 6.3853 mL 12.7706 mL 31.9264 mL
10 mM 0.6385 mL 3.1926 mL 6.3853 mL 15.9632 mL
15 mM 0.4257 mL 2.1284 mL 4.2569 mL 10.6421 mL
20 mM 0.3193 mL 1.5963 mL 3.1926 mL 7.9816 mL
25 mM 0.2554 mL 1.2771 mL 2.5541 mL 6.3853 mL
30 mM 0.2128 mL 1.0642 mL 2.1284 mL 5.3211 mL
40 mM 0.1596 mL 0.7982 mL 1.5963 mL 3.9908 mL
50 mM 0.1277 mL 0.6385 mL 1.2771 mL 3.1926 mL
60 mM 0.1064 mL 0.5321 mL 1.0642 mL 2.6605 mL
80 mM 0.0798 mL 0.3991 mL 0.7982 mL 1.9954 mL
100 mM 0.0639 mL 0.3193 mL 0.6385 mL 1.5963 mL
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Chloroxylenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloroxylenol88-04-0p-chloro-m-xylenolBacterialInfluenza VirusParasiteHCT116SW480CRCMC38xenografttumorInhibitorinhibitorinhibit

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