2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Clenbuterol hydrochloride

Clenbuterol hydrochloride  (Synonyms: NAB-365 hydrochloride)

Cat. No.: HY-B1614 Purity: 99.98%
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Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

For research use only. We do not sell to patients.

Clenbuterol hydrochloride Chemical Structure

Clenbuterol hydrochloride Chemical Structure

CAS No. : 21898-19-1

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5 mg USD 103 In-stock
10 mg USD 160 In-stock
25 mg USD 330 In-stock
50 mg USD 520 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Clenbuterol hydrochloride:

Clenbuterol hydrochloride Related Antibodies

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Description

Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage[1][2][3].

In Vitro

Clenbuterol increases lipolysis in rat primary adipocytes compared with control. Free glycerol release into the culture medium is 158% and 190% of control values in cultures containing 0.1, or 1 μM Clenbuterol, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clenbuterol hydrochloride Related Antibodies
In Vivo

Clenbuterol (0.01-0.5 mg/kg; i.p.; male Long-Evans rats) hydrochloride reduces the cortical infarct volume in Long-Evans rats as measured 7 days after permanent occlusion of the middle cerebral artery[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

313.65

Formula

C12H19Cl3N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)(C)C)C1=CC(Cl)=C(N)C(Cl)=C1.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (265.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1883 mL 15.9413 mL 31.8827 mL
5 mM 0.6377 mL 3.1883 mL 6.3765 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

COA (248 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

MTS assay is performed to determine the number of viable cells in culture. Cells are treated with 0 (vehicle only), 0.1, or 1 μM Clenbuterol for 6, 12, 24, or 48 h. The absorbance is measured at 490 nm in a plate reader determine the formazan concentration, which is proportional to the number of living cells in culture[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Rats:
Rats are randomly divided into two treatment groups. The control group is provided with standard chow and water ad libitum for 3 weeks, while the Clenbuterol group is provided with standard chow and treated for 3 weeks with Clenbuterol administered via the drinking water (30 mg Clenbuterol/L). Body weight and the amount of water consumed are recorded twice each week. After 3 wk, the animals are anesthetized and hindlimb muscles are excised[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1883 mL 15.9413 mL 31.8827 mL 79.7067 mL
5 mM 0.6377 mL 3.1883 mL 6.3765 mL 15.9413 mL
10 mM 0.3188 mL 1.5941 mL 3.1883 mL 7.9707 mL
15 mM 0.2126 mL 1.0628 mL 2.1255 mL 5.3138 mL
20 mM 0.1594 mL 0.7971 mL 1.5941 mL 3.9853 mL
25 mM 0.1275 mL 0.6377 mL 1.2753 mL 3.1883 mL
30 mM 0.1063 mL 0.5314 mL 1.0628 mL 2.6569 mL
40 mM 0.0797 mL 0.3985 mL 0.7971 mL 1.9927 mL
50 mM 0.0638 mL 0.3188 mL 0.6377 mL 1.5941 mL
60 mM 0.0531 mL 0.2657 mL 0.5314 mL 1.3284 mL
80 mM 0.0399 mL 0.1993 mL 0.3985 mL 0.9963 mL
100 mM 0.0319 mL 0.1594 mL 0.3188 mL 0.7971 mL
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Clenbuterol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clenbuterol21898-19-1NAB-365NAB365NAB 365Adrenergic ReceptorBeta ReceptorastrocytesischemicdamageskeletalmusclestrengthhypertrophyInhibitorinhibitorinhibit

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