2. Academic Validation
  3. Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y

Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y

  • Adv Sci (Weinh). 2021 Dec;8(24):e2100808. doi: 10.1002/advs.202100808.
Yan Zhang 1 2 3 4,  Chun-Yuan Chen 1 2,  Yi-Wei Liu 1 2 4,  Shan-Shan Rao 2 5,  Yi-Juan Tan 2,  Yu-Xuan Qian 1 2,  Kun Xia 1 2,  Jie Huang 1 2,  Xi-Xi Liu 6,  Chun-Gu Hong 2,  Hao Yin 1 2,  Jia Cao 1 2,  Shi-Kai Feng 1 2 4,  Ze-Hui He 1 2,  You-You Li 1 2,  Zhong-Wei Luo 1 2,  Ben Wu 1,  Zi-Qi Yan 1,  Tuan-Hui Chen 1,  Meng-Lu Chen 4,  Yi-Yi Wang 1 2,  Zhen-Xing Wang 1 2,  Zheng-Zhao Liu 1 2 4 7,  Ming-Jie Luo 2 5,  Xiong-Ke Hu 1 2,  Ling Jin 1 2,  Teng-Fei Wan 1 2,  Tao Yue 1 2,  Si-Yuan Tang 5,  Hui Xie 1 2 4 7 8 9
Affiliations

Affiliations

  • 1 Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 2 Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 3 Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • 4 Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 5 Xiangya School of Nursing, Central South University, Changsha, Hunan, 410013, China.
  • 6 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
  • 7 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • 8 Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Xiangya Hospital, Central South University, Changsha, Changsha, Hunan, 410008, China.
  • 9 Hunan Key Laboratory of Bone Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, Changsha, Hunan, 410008, China.
PMID: 34719888 DOI: 10.1002/advs.202100808
Abstract

A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age- and menopause-associated bone loss and marrow adiposity. Here it is found that osteocytes, the most abundant bone cells, promote adipogenesis and inhibit osteogenesis of BMSCs by secreting neuropeptide Y (NPY), whose expression increases with aging and osteoporosis. Deletion of NPY in osteocytes generates a high bone mass phenotype, and attenuates aging- and ovariectomy (OVX)-induced bone-fat imbalance in mice. Osteocyte NPY production is under the control of autonomic nervous system (ANS) and osteocyte NPY deletion blocks the ANS-induced regulation of BMSC fate and bone-fat balance. γ-Oryzanol, a clinically used ANS regulator, significantly increases bone formation and reverses aging- and OVX-induced osteocyte NPY overproduction and marrow adiposity in control mice, but not in mice lacking osteocyte NPY. The study suggests a new mode of neuronal control of bone metabolism through the ANS-induced regulation of osteocyte NPY.

Keywords

adipogenesis; autonomic nervous system; bone marrow mesenchymal stem/stromal cells; neuropeptide Y; osteocyte; osteogenesis.

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