D-Alanine (Synonyms: (R)-Alanine; Ba 2776; D-α-Alanine)

Cat. No.: HY-41700 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR.

For research use only. We do not sell to patients.

D-Alanine Chemical Structure

CAS No. : 338-69-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 g	USD 60	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Other Forms of D-Alanine:

D-Alanine-d₃ Get quote
D-Alanine-d₄ Get quote
D-Alanine-d Get quote
D-Alanine-d₇ Get quote
DL-Alanine Get quote
D-Alanine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC₅₀ of 9 mM for GlyR^[1]^[2].

IC₅₀ & Target^[1]^[2]

Microbial Metabolite

GlyR

9 mM (EC₅₀)

PMBA

Human Endogenous Metabolite

In Vitro

D-Alanine induces dose-dependent depolarization of motoneurones in newborn rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-Alanine (100 mg/kg, p.o.) together with CBIO (30 mg/kg) relieves Dizocilpine (0.1 mg/kg)-induced prepulse inhibition deficits in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

89.09

Formula

C₃H₇NO₂

CAS No.

338-69-2

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(O)=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 120 mg/mL (1346.95 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	11.2246 mL	56.1230 mL	112.2460 mL
5 mM	2.2449 mL	11.2246 mL	22.4492 mL
10 mM	1.1225 mL	5.6123 mL	11.2246 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (561.23 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (270 KB) SDS (394 KB)

COA (244 KB) RP-HPLC (193 KB)

Handling Instructions (2659 KB)

References

[1]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [Content Brief]

[2]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. [Content Brief]

[3]. Mao Horio, et al. Effects of D-Amino Acid Oxidase Inhibitor on the Extracellular D-Alanine Levels and the Efficacy of D-Alanine on Dizocilpine-Induced Prepulse Inhibition Deficits in Mice. The Open Clinical Chemistry Journal, 2009, 2: 16-21

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	11.2246 mL	56.1230 mL	112.2460 mL	280.6151 mL
	5 mM	2.2449 mL	11.2246 mL	22.4492 mL	56.1230 mL
	10 mM	1.1225 mL	5.6123 mL	11.2246 mL	28.0615 mL
	15 mM	0.7483 mL	3.7415 mL	7.4831 mL	18.7077 mL
	20 mM	0.5612 mL	2.8062 mL	5.6123 mL	14.0308 mL
	25 mM	0.4490 mL	2.2449 mL	4.4898 mL	11.2246 mL
	30 mM	0.3742 mL	1.8708 mL	3.7415 mL	9.3538 mL
	40 mM	0.2806 mL	1.4031 mL	2.8062 mL	7.0154 mL
	50 mM	0.2245 mL	1.1225 mL	2.2449 mL	5.6123 mL
	60 mM	0.1871 mL	0.9354 mL	1.8708 mL	4.6769 mL
	80 mM	0.1403 mL	0.7015 mL	1.4031 mL	3.5077 mL
	100 mM	0.1122 mL	0.5612 mL	1.1225 mL	2.8062 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

D-Alanine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Alanine338-69-2(R)-Alanine Ba 2776 D-α-AlanineBa2776Ba 2776Ba-2776Endogenous MetaboliteweakGlyRinhibitoryglycinePMBAInhibitorinhibitorinhibit

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