2. Anti-infection
  3. Parasite SARS-CoV
  4. Diiodohydroxyquinoline

Diiodohydroxyquinoline  (Synonyms: Iodoquinol; 5,7-Diiodo-8-hydroxyquinoline; 5,7-Diiodo-8-quinolinol)

Cat. No.: HY-B1400 Purity: ≥98.0%
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Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas.

For research use only. We do not sell to patients.

Diiodohydroxyquinoline Chemical Structure

Diiodohydroxyquinoline Chemical Structure

CAS No. : 83-73-8

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Diiodohydroxyquinoline:

Diiodohydroxyquinoline Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Diiodohydroxyquinoline

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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  • Purity & Documentation

  • References

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Description

Diiodohydroxyquinoline (Iodoquinol, 5,7-Diiodo-8-hydroxyquinoline, 5,7-Diiodo-8-quinolinol) has an orally active and satisfactory antiparasitic properties. Diiodohydroxyquinoline exhibits mutagenic potential in mice and potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells. Diiodohydroxyquinoline's antimutagen is ascorbic acid. Diiodohydroxyquinoline is promising for research in inflammationin, testinal amebiasis, amebic liver abscess and chronic nonspecific diarrheas[1][2][3][4][5].
Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 25 μM
Compound: 60; MMV002817
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
[PMID: 30647879]
In Vitro

Diiodohydroxyquinoline (0-10 μM, 72 h) inhibits the viral load, viral antigen expression and infectious viral particle production of SARS-CoV-2, and protected SARS-CoV-2-induced cell damages similar to Remdesivir (HY-104077) in vero E6 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diiodohydroxyquinoline Related Antibodies

Real Time qPCR[3]

Cell Line: Caco2 cells
Concentration: 0-10 μM
Incubation Time: 48 h
Result: Exhibited dose-dependent viral load reduction in SARS-CoV-2-infected Caco2 (human colorectal adenocarcinoma) cell culture supernatants and cell lysates.
In Vivo

Diiodohydroxyquinoline (80 mg/kg, p.o., a single dose for 24 h) exhibits mutagenic activity dose-dependently in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice (6 weeks old and weighing about 20 g) [2]
Dosage: 80 mg/kg
Administration: p.o., a single dose for 24 h
Result: Showed mutagenic activity dose-dependently in Swiss albino mice.
Molecular Weight

396.95

Formula

C9H5I2NO
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C2N=CC=CC2=C(I)C=C1I
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (52.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5192 mL 12.5960 mL 25.1921 mL
5 mM 0.5038 mL 2.5192 mL 5.0384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (6.30 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

SDS (614 KB)

COA (252 KB) HNMR (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5192 mL 12.5960 mL 25.1921 mL 62.9802 mL
5 mM 0.5038 mL 2.5192 mL 5.0384 mL 12.5960 mL
10 mM 0.2519 mL 1.2596 mL 2.5192 mL 6.2980 mL
15 mM 0.1679 mL 0.8397 mL 1.6795 mL 4.1987 mL
20 mM 0.1260 mL 0.6298 mL 1.2596 mL 3.1490 mL
25 mM 0.1008 mL 0.5038 mL 1.0077 mL 2.5192 mL
30 mM 0.0840 mL 0.4199 mL 0.8397 mL 2.0993 mL
40 mM 0.0630 mL 0.3149 mL 0.6298 mL 1.5745 mL
50 mM 0.0504 mL 0.2519 mL 0.5038 mL 1.2596 mL
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Diiodohydroxyquinoline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diiodohydroxyquinoline83-73-8Iodoquinol 5,7-Diiodo-8-hydroxyquinoline 5,7-Diiodo-8-quinolinolParasiteSARS-CoVSARS coronavirusorally activeantibacterialantiparasiticmutagenic potentialanti-SARS-CoV-2 activityinflammationintestinal amebiasis amebic liver abscessInhibitorinhibitorinhibit

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