2. Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Cuproptosis Reactive Oxygen Species
  4. Emeramide

Emeramide  (Synonyms: NBMI; BDTH2)

Cat. No.: HY-16739 Purity: 99.56%
COA Handling Instructions

Molarity Calculator

Emeramide is a thiol-redox antioxidant and heavy metal chelator.

For research use only. We do not sell to patients.

Emeramide Chemical Structure

Emeramide Chemical Structure

CAS No. : 351994-94-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Emeramide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Emeramide is a thiol-redox antioxidant and heavy metal chelator[1].

In Vitro

Emeramide (50 μM, 1 h) protects cell from Bleomycin (HY-108345)-induced cell (BPAECs) morphology alterations and cytotoxicity, and inhibits ROS generation, attenuates the Bleomycin-induced loss of cellular total thiols[2].
Emeramide (0-100 μM, pretreated for 24 h) inhibits Pb-induced neuroinflammation by reducing IL-1β and GFAP expression levels in U-87 MG cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emeramide Related Antibodies
In Vivo

Emeramide (450 mg/kg, daily, p.o., 6 weeks) decreases iron accumulation in Hfe H67D mutant mice ( a mouse model of brain iron accumulation)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

284.40

Formula

C12H16N2O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (351.62 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5162 mL 17.5809 mL 35.1617 mL
5 mM 0.7032 mL 3.5162 mL 7.0323 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (7.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (7.31 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.56%

COA (242 KB) HNMR (183 KB) LCMS (348 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5162 mL 17.5809 mL 35.1617 mL 87.9044 mL
5 mM 0.7032 mL 3.5162 mL 7.0323 mL 17.5809 mL
10 mM 0.3516 mL 1.7581 mL 3.5162 mL 8.7904 mL
15 mM 0.2344 mL 1.1721 mL 2.3441 mL 5.8603 mL
20 mM 0.1758 mL 0.8790 mL 1.7581 mL 4.3952 mL
25 mM 0.1406 mL 0.7032 mL 1.4065 mL 3.5162 mL
30 mM 0.1172 mL 0.5860 mL 1.1721 mL 2.9301 mL
40 mM 0.0879 mL 0.4395 mL 0.8790 mL 2.1976 mL
50 mM 0.0703 mL 0.3516 mL 0.7032 mL 1.7581 mL
60 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4651 mL
80 mM 0.0440 mL 0.2198 mL 0.4395 mL 1.0988 mL
100 mM 0.0352 mL 0.1758 mL 0.3516 mL 0.8790 mL
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Emeramide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emeramide351994-94-0NBMI BDTH2BDTH2BDTH 2BDTH-2CuproptosisReactive Oxygen Speciesthiol-redoxantioxidantheavy metal chelatorInhibitorinhibitorinhibit

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