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  4. High Uric Acid Models
  5. Ethambutol dihydrochloride

Ethambutol dihydrochloride  (Synonyms: Emb dihydrochloride)

Cat. No.: HY-B0535A Purity: 98.75%
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Handling Instructions Technical Support

Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol dihydrochloride can be used to establish animal models of hyperuricemia and optic neuropathy.

For research use only. We do not sell to patients.

Ethambutol dihydrochloride Chemical Structure

Ethambutol dihydrochloride Chemical Structure

CAS No. : 1070-11-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO In-stock
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500 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ethambutol dihydrochloride:

Ethambutol dihydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ethambutol dihydrochloride

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Description

Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol dihydrochloride can be used to establish animal models of hyperuricemia and optic neuropathy.

In Vivo

Ethambutol dihydrochloride can be used in animal modeling to build a model of hyperuricemia.
1. Induction of Hyperuricaemic Disease[4][5]
Background
Elevated uric acid levels can lead to crystal deposition and may cause gout, urolithiasis, and urate nephropathy. Ethambutol dihydrochloride can cause increased uric acid levels by reducing renal uric acid clearance, ultimately leading to hyperuricemia
Specific Modeling Methods
Rat[4]: Male • Wistar rats • SPF • 200-220 g
Administration: 250 mg/kg (Ethambutol) • intragastric administration • once daily for 23 days
Note
(1) Ethambutol dihydrochloride-induced hyperuricemia model should be combined with adenine (HY-B0152) (100 mg/kg; gavage) to achieve better model construction effect[4].
(2) Some compounds can synergistically promote uric acid production, such as: Ethanol and Vitamin B12 (HY-B0315)[5].
(3) Ethambutol dihydrochloride-induced hyperuricemia model can be controlled by xanthine oxidase inhibitors.
Modeling Indicators
Molecular changes: URAT1 level in kidney homogenate ↑, OAT1 level ↓.
Physiological changes: Serum uric acid level ↑; sparse cells, tissue cell number ↑, lymphocyte number ↓.
Pathological changes: Pathological damage and inflammatory response in the thymus and spleen; thymus atrophy, cortical medullary fusion; splenic sinus congestion, with iron-yellow deposits.
Opposite Product(s): Xanthine Oxidase Inhibitors
2. Induction of Optic Neuropathy[6]
Background
Ethambutol dihydrochloride treatment can cause binocular toxicity at certain doses and durations. There is currently no clear treatment to prevent damage to retinal neuronal cells in cases of Ethhambutol dihydrochloride-induced optic neuropathy (EON).
Specific Modeling Methods
Rat: Wistar rats
Administration: 35 mg/kg/day (Ethambutol) • po • 30 days
Modeling Indicators
Molecular changes: Bcl-2, Caspase-3 expression levels ↑.
Pathological indicators: Ganglion cell damage, increased density of retinal ganglion cells (RGCs); thickening of the RGC cell layer due to vacuoles formed in the ganglion cell cytoplasm.
Opposite Product(s): Citicoline (HY-B0739)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

277.23

Formula

C10H26Cl2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](NCCN[C@@H](CC)CO)CO.Cl.Cl
Structure Classification
Initial Source

Mycobacterium smegmatis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (360.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (180.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6071 mL 18.0356 mL 36.0711 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (360.71 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.6071 mL 18.0356 mL 36.0711 mL 90.1778 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL 18.0356 mL
10 mM 0.3607 mL 1.8036 mL 3.6071 mL 9.0178 mL
15 mM 0.2405 mL 1.2024 mL 2.4047 mL 6.0119 mL
20 mM 0.1804 mL 0.9018 mL 1.8036 mL 4.5089 mL
25 mM 0.1443 mL 0.7214 mL 1.4428 mL 3.6071 mL
30 mM 0.1202 mL 0.6012 mL 1.2024 mL 3.0059 mL
40 mM 0.0902 mL 0.4509 mL 0.9018 mL 2.2544 mL
50 mM 0.0721 mL 0.3607 mL 0.7214 mL 1.8036 mL
60 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5030 mL
80 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1272 mL
100 mM 0.0361 mL 0.1804 mL 0.3607 mL 0.9018 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ethambutol dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethambutol1070-11-7EmbBacterialAntibioticInhibitorinhibitorinhibit

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