2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Dopamine Receptor Apoptosis
  4. Fenoldopam mesylate

Fenoldopam mesylate  (Synonyms: Fenoldopam methanesulfonate; SKF-82526 mesylate)

Cat. No.: HY-B0735A Purity: 99.94%
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Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.

For research use only. We do not sell to patients.

Fenoldopam mesylate Chemical Structure

Fenoldopam mesylate Chemical Structure

CAS No. : 67227-57-0

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10 mM * 1 mL in DMSO
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50 mg USD 187 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Fenoldopam mesylate:

Fenoldopam mesylate Related Antibodies

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Description

Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

IC50 & Target

IC50: 0.8974 μM (LSD1)[2]
In Vitro

Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells[1].
Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines[2].
Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fenoldopam mesylate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: 786-O, ACHN, and HK-2 cells
Concentration: 0-300 μM
Incubation Time: 48 or 72 hours
Result: Inhibited the growth of ACHN cells (IC50=16.55 μM, 48 h; IC50=10.34 μM, 72 h), 786-O cells (IC50=57.89 μM, 48 h; IC50=47.52 μM, 72 h), and HK2 cells (IC50>300 μM, 48h and 72 h).

Apoptosis Analysis[1]

Cell Line: ACHN cells
Concentration: 5 μM and 10 μM
Incubation Time: 72 hours
Result: Increased apoptotic cells from at 2.2% (control) to 47.7% (5 μM, fenoldopam) and 60.8% (10 μM, fenoldopam), respectively.
In Vivo

Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats[3]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result: Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.
Observed perivascular edema histopathologically.
Clinical Trial
Molecular Weight

401.86

Formula

C17H20ClNO6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (89.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (24.88 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4884 mL 12.4421 mL 24.8843 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (393 KB)

COA (251 KB) HNMR (269 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4884 mL 12.4421 mL 24.8843 mL 62.2107 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL 12.4421 mL
10 mM 0.2488 mL 1.2442 mL 2.4884 mL 6.2211 mL
15 mM 0.1659 mL 0.8295 mL 1.6590 mL 4.1474 mL
20 mM 0.1244 mL 0.6221 mL 1.2442 mL 3.1105 mL
DMSO 25 mM 0.0995 mL 0.4977 mL 0.9954 mL 2.4884 mL
30 mM 0.0829 mL 0.4147 mL 0.8295 mL 2.0737 mL
40 mM 0.0622 mL 0.3111 mL 0.6221 mL 1.5553 mL
50 mM 0.0498 mL 0.2488 mL 0.4977 mL 1.2442 mL
60 mM 0.0415 mL 0.2074 mL 0.4147 mL 1.0368 mL
80 mM 0.0311 mL 0.1555 mL 0.3111 mL 0.7776 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fenoldopam mesylate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenoldopam67227-57-0SKF-82526SKF82526SKF 82526Dopamine ReceptorApoptosislysine-specific demethylase 1 inhibitoranti-hypertensive activityanti-proliferation activity786-OACHNHK-2LLC-PK1Inhibitorinhibitorinhibit

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