Imidazoleacetic acid (Synonyms: Imidazolyl-4-acetic acid)

Cat. No.: HY-113413 Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

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Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors.

For research use only. We do not sell to patients.

Imidazoleacetic acid Chemical Structure

CAS No. : 645-65-8

Size	Price	Stock	Quantity
10 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Imidazoleacetic acid:

Imidazoleacetic acid hydrochloride Get quote
Imidazoleacetic acid (Standard) Get quote

1 Publications Citing Use of MCE Imidazoleacetic acid

•FASEB J. 2022 May;36(5):e22305. [Abstract]

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Biological Activity
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Description

Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors.

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	13 μM Compound: 4, IAA	Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay	[PMID: 17655213]
HEK293	EC₅₀	138 μM Compound: 4, IAA	Agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]
HEK293	EC₅₀	20 μM Compound: 4, IAA	Agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]
HEK293	EC₅₀	5.5 μM Compound: 4, IAA	Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]

Molecular Weight

126.11

Formula

C₅H₆N₂O₂

CAS No.

645-65-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC1=CN=CN1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL (66.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.9296 mL	39.6479 mL	79.2959 mL
5 mM	1.5859 mL	7.9296 mL	15.8592 mL
10 mM	0.7930 mL	3.9648 mL	7.9296 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (248 KB) HNMR (246 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.9296 mL	39.6479 mL	79.2959 mL	198.2396 mL
	5 mM	1.5859 mL	7.9296 mL	15.8592 mL	39.6479 mL
	10 mM	0.7930 mL	3.9648 mL	7.9296 mL	19.8240 mL
	15 mM	0.5286 mL	2.6432 mL	5.2864 mL	13.2160 mL
	20 mM	0.3965 mL	1.9824 mL	3.9648 mL	9.9120 mL
	25 mM	0.3172 mL	1.5859 mL	3.1718 mL	7.9296 mL
	30 mM	0.2643 mL	1.3216 mL	2.6432 mL	6.6080 mL
	40 mM	0.1982 mL	0.9912 mL	1.9824 mL	4.9560 mL
	50 mM	0.1586 mL	0.7930 mL	1.5859 mL	3.9648 mL
	60 mM	0.1322 mL	0.6608 mL	1.3216 mL	3.3040 mL

Imidazoleacetic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imidazoleacetic acid645-65-8Imidazolyl-4-acetic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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Imidazoleacetic acid (Synonyms: Imidazolyl-4-acetic acid)

Customer Review

Other Forms of Imidazoleacetic acid:

Imidazoleacetic acid Related Antibodies

1 Publications Citing Use of MCE Imidazoleacetic acid

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•Related Screening Libraries:

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Biological Activity

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Customer Review

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Complete Stock Solution Preparation Table

Imidazoleacetic acid Related Classifications

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