2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Imidazoleacetic acid hydrochloride

Imidazoleacetic acid hydrochloride  (Synonyms: Imidazolyl-4-acetic acid hydrochloride)

Cat. No.: HY-W007686 Purity: 99.20%
COA Handling Instructions

Molarity Calculator

2-(1H-Imidazol-5-yl)acetic acid hydrochloride is an endogenous metabolite.

For research use only. We do not sell to patients.

Imidazoleacetic acid hydrochloride Chemical Structure

Imidazoleacetic acid hydrochloride Chemical Structure

CAS No. : 3251-69-2

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Imidazoleacetic acid hydrochloride:

Imidazoleacetic acid hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Imidazoleacetic acid hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-(1H-Imidazol-5-yl)acetic acid hydrochloride is an endogenous metabolite.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Molecular Weight

162.57

Formula

C5H7ClN2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CC1=CN=CN1.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (615.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (307.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1512 mL 30.7560 mL 61.5120 mL
5 mM 1.2302 mL 6.1512 mL 12.3024 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (615.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.65%

COA (249 KB) HNMR (123 KB) RP-HPLC (156 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.1512 mL 30.7560 mL 61.5120 mL 153.7799 mL
5 mM 1.2302 mL 6.1512 mL 12.3024 mL 30.7560 mL
10 mM 0.6151 mL 3.0756 mL 6.1512 mL 15.3780 mL
15 mM 0.4101 mL 2.0504 mL 4.1008 mL 10.2520 mL
20 mM 0.3076 mL 1.5378 mL 3.0756 mL 7.6890 mL
25 mM 0.2460 mL 1.2302 mL 2.4605 mL 6.1512 mL
30 mM 0.2050 mL 1.0252 mL 2.0504 mL 5.1260 mL
40 mM 0.1538 mL 0.7689 mL 1.5378 mL 3.8445 mL
50 mM 0.1230 mL 0.6151 mL 1.2302 mL 3.0756 mL
60 mM 0.1025 mL 0.5126 mL 1.0252 mL 2.5630 mL
80 mM 0.0769 mL 0.3844 mL 0.7689 mL 1.9222 mL
100 mM 0.0615 mL 0.3076 mL 0.6151 mL 1.5378 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imidazoleacetic acid hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imidazoleacetic acid3251-69-2Imidazolyl-4-acetic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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