2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Imlunestrant

Imlunestrant  (Synonyms: LY-3484356)

Cat. No.: HY-145572 Purity: 99.02%
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Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC).

For research use only. We do not sell to patients.

Imlunestrant Chemical Structure

Imlunestrant Chemical Structure

CAS No. : 2408840-26-4

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1 mg USD 450 In-stock
5 mg USD 1150 In-stock
10 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Imlunestrant:

Imlunestrant Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2].

In Vitro

LY3484356 shows favorable pharmacokinetic (PK) properties, including antitumor activity in ESR1 mutants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imlunestrant Related Antibodies
Clinical Trial
Molecular Weight

524.51

Formula

C29H24F4N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC2=NC=C(C3=CC=C(C(F)(F)F)C=C3O[C@]4([H])C5=CC=C(C=C5)OCCN6CC(C6)CF)C4=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (476.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9065 mL 9.5327 mL 19.0654 mL
5 mM 0.3813 mL 1.9065 mL 3.8131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9065 mL 9.5327 mL 19.0654 mL 47.6635 mL
5 mM 0.3813 mL 1.9065 mL 3.8131 mL 9.5327 mL
10 mM 0.1907 mL 0.9533 mL 1.9065 mL 4.7664 mL
15 mM 0.1271 mL 0.6355 mL 1.2710 mL 3.1776 mL
20 mM 0.0953 mL 0.4766 mL 0.9533 mL 2.3832 mL
25 mM 0.0763 mL 0.3813 mL 0.7626 mL 1.9065 mL
30 mM 0.0636 mL 0.3178 mL 0.6355 mL 1.5888 mL
40 mM 0.0477 mL 0.2383 mL 0.4766 mL 1.1916 mL
50 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.9533 mL
60 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7944 mL
80 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
100 mM 0.0191 mL 0.0953 mL 0.1907 mL 0.4766 mL
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Imlunestrant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imlunestrant2408840-26-4LY-3484356LY3484356LY 3484356Estrogen Receptor/ERRSERDER+HER2breast cancerInhibitorinhibitorinhibit

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