2. Immunology/Inflammation
  3. NO Synthase
  4. Kuwanon A

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

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Kuwanon A Chemical Structure

Kuwanon A Chemical Structure

CAS No. : 62949-77-3

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Solution
10 mM * 1 mL in DMSO USD 277 In-stock
Solid
2 mg USD 131 In-stock
5 mg USD 252 In-stock
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Based on 1 publication(s) in Google Scholar

Kuwanon A Related Antibodies

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1 Publications Citing Use of MCE Kuwanon A

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Description

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

IC50 & Target

IC50: 10.5 μM (nitric oxide)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
5.3 μM
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
In Vitro

Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC50 of 10.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kuwanon A Related Antibodies
Molecular Weight

420.45

Formula

C25H24O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C/C=C(C)\C)=C(C2=C3C(C=CC(C)(C)O3)=C(O)C=C2)OC4=CC(O)=CC(O)=C14
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.69%

Data Sheet (275 KB) SDS (393 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Kuwanon A Related Classifications

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Keywords:

Kuwanon A62949-77-3NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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