2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Carnosine

L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging.

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L-Carnosine Chemical Structure

L-Carnosine Chemical Structure

CAS No. : 305-84-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of L-Carnosine:

L-Carnosine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
28 μM
Compound: 439224
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
10.5281/zenodo.7360449
SH-SY5Y EC50
3 μM
Compound: Carnosine
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
[PMID: 27420919]
In Vitro

L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1].
L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Carnosine Related Antibodies
Molecular Weight

226.24

Formula

C9H14N4O3
CAS No.
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (368.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4202 mL 22.1008 mL 44.2016 mL
5 mM 0.8840 mL 4.4202 mL 8.8403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (442.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

SDS (394 KB)

COA (250 KB) HNMR (204 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.4202 mL 22.1008 mL 44.2016 mL 110.5041 mL
5 mM 0.8840 mL 4.4202 mL 8.8403 mL 22.1008 mL
10 mM 0.4420 mL 2.2101 mL 4.4202 mL 11.0504 mL
15 mM 0.2947 mL 1.4734 mL 2.9468 mL 7.3669 mL
20 mM 0.2210 mL 1.1050 mL 2.2101 mL 5.5252 mL
25 mM 0.1768 mL 0.8840 mL 1.7681 mL 4.4202 mL
30 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6835 mL
40 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7626 mL
50 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2101 mL
60 mM 0.0737 mL 0.3683 mL 0.7367 mL 1.8417 mL
80 mM 0.0553 mL 0.2763 mL 0.5525 mL 1.3813 mL
100 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Carnosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Carnosine305-84-0Endogenous MetaboliteInhibitorinhibitorinhibit

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