Neuropathiazol

Cat. No.: HY-10591 Purity: 98.73%: FAQs
Data Sheet SDS COA Handling Instructions

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Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.

For research use only. We do not sell to patients.

Neuropathiazol Chemical Structure

CAS No. : 880090-88-0

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10 mM * 1 mL in DMSO ready for reconstitution	USD 161	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 161	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 153	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 468	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells^[1].

In Vitro

Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects^[1].
Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker)^[1].
Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2^[1].
Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells^[1].
Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HCN cells
Concentration:	5 μM, 10 μM, 15 μM
Incubation Time:	5 hours
Result:	Inhibited proliferation of HCN neural progenitor cells.

RT-PCR^[1]

Cell Line:	HCN cells
Concentration:	10 μM
Incubation Time:	1 day, 4 days
Result:	Downregulated Sox2 and upregulated NeuroD1.

Molecular Weight

338.42

Formula

C₁₉H₁₈N₂O₂S

CAS No.

880090-88-0

Appearance

Solid

Color

Light brown to brown

SMILES

CN(C1=CC=C(C(OCC)=O)C=C1)C2=CSC(C3=CC=CC=C3)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (98.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9549 mL	14.7745 mL	29.5491 mL
5 mM	0.5910 mL	2.9549 mL	5.9098 mL
10 mM	0.2955 mL	1.4775 mL	2.9549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.73%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. Warashina M, et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16;45(4):591-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9549 mL	14.7745 mL	29.5491 mL	73.8727 mL
	5 mM	0.5910 mL	2.9549 mL	5.9098 mL	14.7745 mL
	10 mM	0.2955 mL	1.4775 mL	2.9549 mL	7.3873 mL
	15 mM	0.1970 mL	0.9850 mL	1.9699 mL	4.9248 mL
	20 mM	0.1477 mL	0.7387 mL	1.4775 mL	3.6936 mL
	25 mM	0.1182 mL	0.5910 mL	1.1820 mL	2.9549 mL
	30 mM	0.0985 mL	0.4925 mL	0.9850 mL	2.4624 mL
	40 mM	0.0739 mL	0.3694 mL	0.7387 mL	1.8468 mL
	50 mM	0.0591 mL	0.2955 mL	0.5910 mL	1.4775 mL
	60 mM	0.0492 mL	0.2462 mL	0.4925 mL	1.2312 mL
	80 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9234 mL

Neuropathiazol Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuropathiazol880090-88-0OthersneuronaldifferentiationneuralstemcellsneurodegenerativediseaseInhibitorinhibitorinhibit

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