2. Immunology/Inflammation Apoptosis Anti-infection
  3. Toll-like Receptor (TLR) Apoptosis TNF Receptor HCV Interleukin Related
  4. PF-4878691

PF-4878691  (Synonyms: 3M-852A)

Cat. No.: HY-100176 Purity: 99.64%
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PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer.

For research use only. We do not sell to patients.

PF-4878691 Chemical Structure

PF-4878691 Chemical Structure

CAS No. : 532959-63-0

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Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Solid
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Based on 1 publication(s) in Google Scholar

PF-4878691 Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].

IC50 & Target

TLR7

 

IL-6

 

IL-8

 

IL-1β

 

IL-2

 

In Vitro

PF-4878691 (10 μM, 4 h) induces a complex transcription network responsible for activating plasmacytoid dendritic cells for innate antiviral immune responses with optimized responses towards RNA viruses, increases co-stimulatory capacity, and increases survival in plasmacytoid dendritic cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4878691 Related Antibodies
In Vivo

PF-4878691 (10-150 mg, Oral gavage, single dose) induces pharmacology in BALB/c mice and C57bl/6 J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice , C57bl/6 J mice[3]
Dosage: 30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg
Administration: Oral gavage (p.o.)
Result: Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).
Caused cardiovascular changes.
Significantly increased TLR7 receptor RNA.
Molecular Weight

361.46

Formula

C17H23N5O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 99.89%

COA (253 KB) HNMR (158 KB) LCMS (345 KB)

Handling Instructions (2659 KB)
References
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PF-4878691 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-4878691532959-63-03M-852APF4878691PF 4878691Toll-like Receptor (TLR)ApoptosisTNF ReceptorHCVInterleukin RelatedTumor Necrosis Factor ReceptorTNFRHepatitis C virusILplasmacytoid dendritic cellsagonisthealthy subjectscancerantiviralInhibitorinhibitorinhibit

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