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  4. Polyvinylpyrrolidone K30

Polyvinylpyrrolidone K30  (Synonyms: PVP K30; Polyvidone K30; Povidone K30)

Cat. No.: HY-B1620 Purity: 99.38%
COA Handling Instructions

Molarity Calculator

Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.

For research use only. We do not sell to patients.

Polyvinylpyrrolidone K30 Chemical Structure

Polyvinylpyrrolidone K30 Chemical Structure

CAS No. : 9003-39-8

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Polyvinylpyrrolidone K30 Related Antibodies

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  • Protocol

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Description

Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.

In Vivo

Goldfishes which are treated with salt have significantly lower mucus weights at 25 h. Goldfishes treated with Polyvinylpyrrolidone K30 have significantly higher mucus weights at 25 h. Koi treated with salt and Polyvinylpyrrolidone K30 has significantly lower mucus weight at 1 and 25 h. Control koi has significantly higher mucus at 25 h. At the end of 2 weeks, it is determined that the three koi treated with salt and Polyvinylpyrrolidone K30 remain healthy and show a higher degree of healing than other treatment koi and the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

111.1418 (monomer)

Formula

(C6H9NO)n
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1CCCN1C(C[H])[H].[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL

DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.38%

COA (248 KB) HNMR (276 KB) RP-HPLC (219 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Each fish within a tank serves as a replicate. Treatments are designated as Polyvinylpyrrolidone (at a dose of 10 mL/10 gallon) and saline/salt at 3g/L. A control group that does not receive any chemical is also included in the study. All fishes from each treatment group are sampled at 0 min, 15 min, 1 h, 4 h and 25 h. At each time interval, all fishes from each treatment group are anaesthetized using buffered tricaine methanesulfonate, weighed, and slime is scraped from one 1 cm2 area over the epaxial musculature using a preweighed plastic coverslip[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Polyvinylpyrrolidone K30 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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