RG7800 (Synonyms: RO6885247)

Name: RG7800
Brand: MedChemExpress
SKU: HY-101792
Rating: 5.0 (5 reviews)

Cat. No.: HY-101792 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

For research use only. We do not sell to patients.

RG7800 Chemical Structure

CAS No. : 1449598-06-4

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 5 publication(s) in Google Scholar

Other Forms of RG7800:

RG7800 tetrahydrochloride In-stock

5 Publications Citing Use of MCE RG7800

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Description

RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC₅₀	> 10 μM Compound: 2; RG7800	Dark toxicity in mouse 3T3 cells assessed as decrease in cell viability by neutral red uptake assay Dark toxicity in mouse 3T3 cells assessed as decrease in cell viability by neutral red uptake assay	[PMID: 30044619]
NIH3T3	IC₅₀	330 nM Compound: 2; RG7800	Phototoxicity in mouse 3T3 cells assessed as decrease in cell viability in presence of UV light by neutral red uptake assay Phototoxicity in mouse 3T3 cells assessed as decrease in cell viability in presence of UV light by neutral red uptake assay	[PMID: 30044619]

In Vitro

RG7800 increases the SMN protein level via induction of alternative splicing of the SMN2 mRNA. RG7800 is shown to promote the inclusion of exon 7 in SMN2 mRNA, generating full-length mRNA in vitro using fibroblasts from an SMA type I patient^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RG7800 shows favorable drug metabolism and pharmacokinetic profile in the rat and in cynomolgus monkey with good oral bioavailability. In SMA mouse model, treatment of RG7800 shows a clear dose dependent increase in SMN protein levels. Mice treated with RG7800 demonstrate a dose dependent increase in survival beginning at the low dose (0.3/1 mg/kg). In the middle and high dose groups (1/3 and 3/10 mg/kg, respectively), approximately 80?90% survive beyond PND50/PND60 with profound body weight gain when the study is terminated. RG7800 dose-dependently corrects SMN2 splicing by including exon 7 to create FL mRNA, suggesting that RG7800 corrects alternative splicing of the human SMN2 gene in the brain of transgenic SMA model mice, leading to an increase of the SMN protein in the brain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

416.52

Formula

C₂₄H₂₈N₆O

CAS No.

1449598-06-4

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

1 M HCL : 100 mg/mL (240.08 mM; Need ultrasonic)

Ethanol : 2.5 mg/mL (6.00 mM; Need ultrasonic)

H₂O : 1.25 mg/mL (3.00 mM; ultrasonic and adjust pH to 3 with HCl)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4008 mL	12.0042 mL	24.0085 mL
5 mM	0.4802 mL	2.4008 mL	4.8017 mL
10 mM	0.2401 mL	1.2004 mL	2.4008 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (273 KB) SDS (643 KB)

COA (247 KB) HNMR (199 KB) LCMS (412 KB)

Handling Instructions (2659 KB)

References

[1]. Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100. [Content Brief]

Animal Administration ^[1]	Mice: Compounds (RG7800) are administered orally once daily (qd) for 10 days at three different doses (1, 3, and 10 mg/kg). One hour after the final dose, tissues are collected from the mice, and the level of the SMN protein is determined in the brain and quadriceps muscle^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / Ethanol / 1 M HCL	1 mM	2.4008 mL	12.0042 mL	24.0085 mL	60.0211 mL
Ethanol / 1 M HCL	5 mM	0.4802 mL	2.4008 mL	4.8017 mL	12.0042 mL
1 M HCL	10 mM	0.2401 mL	1.2004 mL	2.4008 mL	6.0021 mL
	15 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0014 mL
	20 mM	0.1200 mL	0.6002 mL	1.2004 mL	3.0011 mL
	25 mM	0.0960 mL	0.4802 mL	0.9603 mL	2.4008 mL
	30 mM	0.0800 mL	0.4001 mL	0.8003 mL	2.0007 mL
	40 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5005 mL
	50 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2004 mL
	60 mM	0.0400 mL	0.2001 mL	0.4001 mL	1.0004 mL
	80 mM	0.0300 mL	0.1501 mL	0.3001 mL	0.7503 mL
	100 mM	0.0240 mL	0.1200 mL	0.2401 mL	0.6002 mL

RG7800 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG78001449598-06-4RO6885247RG 7800RG-7800RO 6885247RO-6885247DNA/RNA SynthesisInhibitorinhibitorinhibit

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RG7800 (Synonyms: RO6885247)

Customer Review

Other Forms of RG7800:

RG7800 Related Antibodies

5 Publications Citing Use of MCE RG7800

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Biological Activity

Protocol

Purity & Documentation

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Customer Review

RG7800 Related Antibodies

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Complete Stock Solution Preparation Table

RG7800 Related Classifications

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