2. Anti-infection
  3. Bacterial
  4. Ribocil-C Racemate

Ribocil-C Racemate is the racemate of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

For research use only. We do not sell to patients.

Ribocil-C Racemate Chemical Structure

Ribocil-C Racemate Chemical Structure

CAS No. : 2309762-18-1

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Other Forms of Ribocil-C Racemate:

Ribocil-C Racemate Related Antibodies

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  • Biological Activity

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  • Purity & Documentation

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Description

Ribocil-C Racemate is the racemate of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

IC50 & Target

Bacterial riboflavin riboswitches[1]
In Vitro

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis[1]. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ribocil-C Racemate Related Antibodies
In Vivo

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

419.50

Formula

C21H21N7OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C2=CC=CS2)NC(C3CCCN(CC4=CN(C5=NC=CC=N5)C=N4)C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (71.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3838 mL 11.9190 mL 23.8379 mL
5 mM 0.4768 mL 2.3838 mL 4.7676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (247 KB) HNMR (205 KB) LCMS (513 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[2]

DBA/2J mice are infected by intraperitoneal injectionwith Escherichia coli strain MB5746 (5×104 CFU per mouse) and treated by subcutaneous injection with Ribocil-C (30, 60, 120 mg/kg) or ciprofloxacin (0.5mg/kg) three times over a 24 h infection period. Spleens are aseptically collected from five mice per group and the reduction of log[CFU per g spleen tissue] is calculated on the basis of bacterial burden in spleens of the vehicle-treated (10% DMSO) control group[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3838 mL 11.9190 mL 23.8379 mL 59.5948 mL
5 mM 0.4768 mL 2.3838 mL 4.7676 mL 11.9190 mL
10 mM 0.2384 mL 1.1919 mL 2.3838 mL 5.9595 mL
15 mM 0.1589 mL 0.7946 mL 1.5892 mL 3.9730 mL
20 mM 0.1192 mL 0.5959 mL 1.1919 mL 2.9797 mL
25 mM 0.0954 mL 0.4768 mL 0.9535 mL 2.3838 mL
30 mM 0.0795 mL 0.3973 mL 0.7946 mL 1.9865 mL
40 mM 0.0596 mL 0.2980 mL 0.5959 mL 1.4899 mL
50 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1919 mL
60 mM 0.0397 mL 0.1986 mL 0.3973 mL 0.9932 mL
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Ribocil-C Racemate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribocil-C2309762-18-1BacterialInhibitorinhibitorinhibit

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