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  4. S-Adenosyl-L-methionine chloride dihydrochloride

S-Adenosyl-L-methionine chloride dihydrochloride  (Synonyms: S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride)

Cat. No.: HY-14614A Purity: ≥75.0%
COA Handling Instructions

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S-(5'-Adenosyl)-L-methionine chloride dihydrochloride is a methyl donor and cofactor.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

S-Adenosyl-L-methionine chloride dihydrochloride Chemical Structure

CAS No. : 86867-01-8

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1 mg USD 25 In-stock
5 mg USD 50 In-stock
10 mg USD 70 In-stock
25 mg USD 98 In-stock
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Based on 11 publication(s) in Google Scholar

Other Forms of S-Adenosyl-L-methionine chloride dihydrochloride:

S-Adenosyl-L-methionine chloride dihydrochloride Related Antibodies

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine chloride dihydrochloride purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

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    Description

    S-(5'-Adenosyl)-L-methionine chloride dihydrochloride is a methyl donor and cofactor.

    Molecular Weight

    507.82

    Formula

    C15H25Cl3N6O5S
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[H]Cl.[H]Cl.[Cl-]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (196.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 50 mg/mL (98.46 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9692 mL 9.8460 mL 19.6920 mL
    5 mM 0.3938 mL 1.9692 mL 3.9384 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥75.0%

    COA (253 KB) HNMR (275 KB) RP-HPLC (262 KB) LCMS (103 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.9692 mL 9.8460 mL 19.6920 mL 49.2300 mL
    5 mM 0.3938 mL 1.9692 mL 3.9384 mL 9.8460 mL
    10 mM 0.1969 mL 0.9846 mL 1.9692 mL 4.9230 mL
    15 mM 0.1313 mL 0.6564 mL 1.3128 mL 3.2820 mL
    20 mM 0.0985 mL 0.4923 mL 0.9846 mL 2.4615 mL
    25 mM 0.0788 mL 0.3938 mL 0.7877 mL 1.9692 mL
    30 mM 0.0656 mL 0.3282 mL 0.6564 mL 1.6410 mL
    40 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2308 mL
    50 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9846 mL
    60 mM 0.0328 mL 0.1641 mL 0.3282 mL 0.8205 mL
    80 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL
    DMSO 100 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4923 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    S-Adenosyl-L-methionine chloride dihydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine chloride86867-01-8S-Adenosyl methionine chlorideAdemetionine chlorideAdoMet chlorideOthersInhibitorinhibitorinhibit

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