Streptonigrin (Synonyms: Bruneomycin)

Cat. No.: HY-124586 Purity: 99.20%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC₅₀s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively.

For research use only. We do not sell to patients.

Streptonigrin Chemical Structure

CAS No. : 3930-19-6

Size	Stock	Quantity
500 μg	In-stock	Estimated Time of Arrival: December 31
1 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

Other Forms of Streptonigrin:

(rac)-Streptonigrin Get quote

1 Publications Citing Use of MCE Streptonigrin

•Sci Signal. 2023 Mar 14;16(776):eabq3362. [Abstract]

: Streptonigrin purchased from MedChemExpress. Usage Cited in: Sci Signal. 2023 Mar 14;16(776):eabq3362. [Abstract]; Streptonigrin (SUMOylation agonist; 2, 4, 8 μM; 48 h) markedly increases the amount of IL-33 protein SUMOylation in Huh7 cells transfected with wild-type IL-33.

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Anti-bacterial^[1]
IC50: 48.3±34.2 µM (PAD1), 26.1±0.3 µM, (PAD2), 0.43±0.03 µM (PAD3), 2.5±0.4 µM (PAD4)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.33 μg/mL Compound: 1	Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay	10.1007/s00044-004-0032-8
A549	IC₅₀	0.33 μg/mL Compound: Streptonigrin	In vitro cytotoxic activity against A 549 (non-small cell lung) using SRB (sulforhodamine B) assay In vitro cytotoxic activity against A 549 (non-small cell lung) using SRB (sulforhodamine B) assay	[PMID: 10328288]
CAKI-1	IC₅₀	0.4 nM Compound: 1	Cytotoxicity against CD30 deficient and CD70 expressing human Caki1 cells after 96 hrs by resazurin conversion assay Cytotoxicity against CD30 deficient and CD70 expressing human Caki1 cells after 96 hrs by resazurin conversion assay	[PMID: 19386499]
HCT-15	IC₅₀	0.02 μg/mL Compound: 1	Cytotoxicity against Homo sapiens (human) HCT15 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) HCT15 cells after 72 hr by MTT assay	10.1007/s00044-004-0032-8
HCT-15	IC₅₀	0.02 μg/mL Compound: Streptonigrin	In vitro cytotoxic activity against HCT-15 (colon) using SRB (sulforhodamine B) assay In vitro cytotoxic activity against HCT-15 (colon) using SRB (sulforhodamine B) assay	[PMID: 10328288]
KARPAS-299	IC₅₀	0.4 nM Compound: 1	Cytotoxicity against CD30 expressing and CD70 deficient human KARPAS299 cells after 96 hrs by resazurin conversion assay Cytotoxicity against CD30 expressing and CD70 deficient human KARPAS299 cells after 96 hrs by resazurin conversion assay	[PMID: 19386499]
SK-MEL-2	IC₅₀	0.02 μg/mL Compound: 1	Cytotoxicity against Homo sapiens (human) SK-MEL-2 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) SK-MEL-2 cells after 72 hr by MTT assay	10.1007/s00044-004-0032-8
SK-MEL-2	IC₅₀	0.02 μg/mL Compound: Streptonigrin	In vitro cytotoxic activity against SK-MEL-2 (melanoma) using SRB (sulforhodamine B) assay In vitro cytotoxic activity against SK-MEL-2 (melanoma) using SRB (sulforhodamine B) assay	[PMID: 10328288]
SK-OV-3	IC₅₀	0.28 μg/mL Compound: 1	Cytotoxicity against Homo sapiens (human) SKOV3 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) SKOV3 cells after 72 hr by MTT assay	10.1007/s00044-004-0032-8
SK-OV-3	IC₅₀	0.28 μg/mL Compound: Streptonigrin	In vitro cytotoxic activity against SK-OV-3 (ovarian) using SRB (sulforhodamine B) assay In vitro cytotoxic activity against SK-OV-3 (ovarian) using SRB (sulforhodamine B) assay	[PMID: 10328288]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
T-cell	IC₅₀	< 20 μM Compound: 1, NSC-45383	Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry	[PMID: 18157122]
XF498	IC₅₀	0.31 μg/mL Compound: 1	Cytotoxicity against Homo sapiens (human) XF498 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) XF498 cells after 72 hr by MTT assay	10.1007/s00044-004-0032-8
XF498	IC₅₀	0.31 μg/mL Compound: Streptonigrin	In vitro cytotoxic activity against XF 498 (CNS) using SRB (sulforhodamine B) assay In vitro cytotoxic activity against XF 498 (CNS) using SRB (sulforhodamine B) assay	[PMID: 10328288]

Molecular Weight

506.46

Formula

C₂₅H₂₂N₄O₈

CAS No.

3930-19-6

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=NC(C2=NC3=C(C(C(OC)=C(N)C3=O)=O)C=C2)=C(N)C(C4=CC=C(OC)C(OC)=C4O)=C1C)O

Structure Classification

Initial Source

Microorganisms

Streptomyces flocculus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.20%

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Data Sheet (270 KB) SDS (251 KB)

COA (251 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9. [Content Brief]

Streptonigrin Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Streptonigrin3930-19-6BruneomycinProtein Arginine DeiminaseAntibioticPeptidylarginine DeiminaseInhibitorinhibitorinhibit

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Streptonigrin (Synonyms: Bruneomycin)

Customer Review

Other Forms of Streptonigrin:

Streptonigrin Related Antibodies

1 Publications Citing Use of MCE Streptonigrin

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Biological Activity

Purity & Documentation

References

Customer Review

Streptonigrin Related Classifications

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The molarity calculator equation

The dilution calculator equation

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