2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. Aldometanib

Aldometanib  (Synonyms: LXY-05-029)

Cat. No.: HY-148189 Purity: 99.73%
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Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.

For research use only. We do not sell to patients.

Aldometanib Chemical Structure

Aldometanib Chemical Structure

CAS No. : 2904601-67-6

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Based on 4 publication(s) in Google Scholar

Aldometanib Related Antibodies

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Description

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1].

In Vitro

Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aldometanib Related Antibodies

Western Blot Analysis[1]

Cell Line: Mouse primary hepatocytes, MEFs cells
Concentration: 0-1000 nM
Incubation Time: 2 h
Result: Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells.

Immunofluorescence[1]

Cell Line: MEFs cells
Concentration: 5 nM
Incubation Time: 2 h
Result: Inhibited TRPVs and induces AXIN lysosomal translocation.
In Vivo

Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice[1].
? Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice[1].
? Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis[1].
? Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice[1].
? Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lean mice[1]
Dosage: 0-10 mpk
Administration: Oral
Result: Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.
Animal Model: Obese hyperglycaemic mice[1]
Dosage: 2-10 mpk
Administration: Oral, twice daily, for a week
Result: Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.
Animal Model: NASH mice[1]
Dosage: 2 mpk
Administration: Oral, twice-daily, for a month
Result: Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.
Animal Model: C. elegans[1]
Dosage: 0-50 μM
Administration: Oral, 0-50 days
Result: Promoted oxidative stress resistance and mitochondrial functions in C. elegans.
Animal Model: C57BL/6 mice[1]
Dosage: 100 μg/mL
Administration: Oral
Result: Extended lifespan, elevated NAD＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
Molecular Weight

593.45

Formula

C27H43Cl2IN2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CCCCCCCCCCCCCCCCN1C=C[N+](CC2=C(Cl)C=CC=C2Cl)=C1C.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (168.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6851 mL 8.4253 mL 16.8506 mL
5 mM 0.3370 mL 1.6851 mL 3.3701 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6851 mL 8.4253 mL 16.8506 mL 42.1265 mL
5 mM 0.3370 mL 1.6851 mL 3.3701 mL 8.4253 mL
10 mM 0.1685 mL 0.8425 mL 1.6851 mL 4.2127 mL
15 mM 0.1123 mL 0.5617 mL 1.1234 mL 2.8084 mL
20 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1063 mL
25 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6851 mL
30 mM 0.0562 mL 0.2808 mL 0.5617 mL 1.4042 mL
40 mM 0.0421 mL 0.2106 mL 0.4213 mL 1.0532 mL
50 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8425 mL
60 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7021 mL
80 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5266 mL
100 mM 0.0169 mL 0.0843 mL 0.1685 mL 0.4213 mL
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Aldometanib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aldometanib2904601-67-6LXY-05-029AMPKAMP-activated protein kinaseoraladenosine monophosphate-activated protein kinase (AMPK)blood glucosemetabolicInhibitorinhibitorinhibit

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