2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor
  5. Angiotensin Receptor Isoform
  6. Angiotensin Receptor Antagonist

Angiotensin Receptor Antagonist

Angiotensin Receptor Antagonists (96):

Cat. No. Product Name Effect Purity
  • HY-W414915R
    Valsartan methyl ester (Standard)
    		Antagonist
    Valsartan methyl ester (Standard) is the analytical standard of Valsartan methyl ester. This product is intended for research and analytical applications. Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC50 of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC50 of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.).
  • HY-17512R
    Losartan (Standard)
    		Antagonist
    Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
  • HY-N9520
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
    		Antagonist
    Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.
  • HY-117627
    L 158338
    		Antagonist
    L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion.
  • HY-B0202AS
    Irbesartan-d7 hydrochloride
    		Antagonist
    Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
  • HY-101574
    Pratosartan
    		Antagonist
    Pratosartan is a selective angiotensin II receptor antagonist.
  • HY-101706
    CGP48369
    		Antagonist
    CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.
  • HY-19191
    L-159282
    		Antagonist
    L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.
  • HY-101618
    L162389
    		Antagonist
    L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
  • HY-106890
    E4177
    		Antagonist
    E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases.
  • HY-131276R
    Olmesartan lactone impurity (Standard)
    		Antagonist
    Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.
  • HY-167886
    GA 0113
    		Antagonist
    GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948)-induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h.
  • HY-14736R
    Azilsartan medoxomil (Standard)
    		Antagonist
    Azilsartan medoxomil (Standard) is the analytical standard of Azilsartan medoxomil. This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
  • HY-U00245
    L162441
    		Antagonist
    L162441 is an Angiotensin type 1 receptor antagonist.
  • HY-U00202
    LY285434
    		Antagonist
    LY285434 is a suitable angiotensin II receptor antagonist.
  • HY-U00188
    A81988
    		Antagonist
    A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors.