2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Antifolate
  5. Antifolate Chemical

Antifolate Chemical

Antifolate Chemicals (19):

Cat. No. Product Name Effect Purity
  • HY-17556
    Folinic acid
    		Chemical 99.90%
    Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
  • HY-13664
    Folinic acid calcium
    		Chemical 99.71%
    Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
  • HY-13667
    Levoleucovorin Calcium
    		Chemical 99.52%
    Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006).
  • HY-17383
    Levomefolate calcium
    		Chemical 99.46%
    Levomefolate calcium is an orally active, blood-brain barrier-crossing form of folate that can be used as a folate food supplement.
  • HY-17557
    Calcium N5-methyltetrahydrofolate
    		Chemical 98.56%
    Calcium N5-methyltetrahydrofolate(NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
  • HY-114306
    EC0489
    		Chemical
    EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. Small molecule-agent conjugate (SMDC).
  • HY-17556B
    Folinic acid calcium hydrate
    		Chemical
    Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
  • HY-17383S
    Levomefolate-13C5 calcium
    		Chemical
    Levomefolate-13C5 (calcium) is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.
  • HY-17556A
    Folinic acid disodium
    		Chemical
    Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma.
  • HY-17557R
    Calcium N5-methyltetrahydrofolate (Standard)
    		Chemical
    Calcium N5-methyltetrahydrofolate (Standard) is the analytical standard of Calcium N5-methyltetrahydrofolate. This product is intended for research and analytical applications. 0
  • HY-121256
    Chlorasquin
    		Chemical
    Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents.
  • HY-162975
    NVP-EVS459 (175Lu)
    		Chemical
    NVP-EVS459 (175Lu) is a folate receptor targeting radio-conjugate, and can be used for cancer research.
  • HY-147699
    FRα-IN-1
    		Chemical
    FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells.
  • HY-17383R
    Levomefolate (calcium) (Standard)
    		Chemical
    Levomefolate (calcium) (Standard) is the analytical standard of Levomefolate (calcium). This product is intended for research and analytical applications. Levomefolate calcium is an orally active, blood-brain barrier-crossing form of folate that can be used as a folate food supplement.
  • HY-13664R
    Folinic acid calcium (Standard)
    		Chemical
    Folinic acid (calcium) (Standard) is the analytical standard of Folinic acid (calcium). This product is intended for research and analytical applications. Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
  • HY-126878
    11-Oxahomoaminopterin
    		Chemical
    11-Oxahomoaminopterin shows antifolate activity and inhibits Lactobacillus casei DHFFZ with antimicrobial and antitumor activities.
  • HY-W654270
    Calcium N5-methyltetrahydrofolate-d3
    		Chemical
    Calcium N5-methyltetrahydrofolate-d3 is deuterium labeled Calcium N5-methyltetrahydrofolate.
  • HY-13667R
    Levoleucovorin Calcium (Standard)
    		Chemical
    Levoleucovorin (Calcium) (Standard) is the analytical standard of Levoleucovorin (Calcium). This product is intended for research and analytical applications. Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer.
  • HY-17556R
    Folinic acid (Standard)
    		Chemical
    Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.