Bcl-2 Family Inhibitor

Bcl-2 Family Inhibitors (199):

Cat. No.	Product Name	Effect	Purity

HY-149672

ABBV-467	Inhibitor	99.78%
ABBV-467 is a selective MCL-1 inhibitor (K_i: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma.

HY-138832

BM-1244	Inhibitor	99.85%
BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with K_is of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC₅₀ of 5 nM. (From patent WO2019033119A1).

HY-146185

CCT373566	Inhibitor	99.12%
CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo.

HY-120897

NS-3-008 hydrochloride	Inhibitor	99.65%
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC₅₀ of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease.

HY-129188

CCT369260	Inhibitor	99.77%
CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC₅₀ of 520 nM.

HY-125911

Gossypin	Inhibitor	98.04%
Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study.

HY-110031

BAI1 hydrochloride	Inhibitor	99.82%
BAI1 hydrochloride is a selective apoptosis factor BAX allosteric inhibitors. BAI1 hydrochloride binds BAX and allosterically inhibits its activation. BAI1 hydrochloride has the potential to be used in the study of BAX dependent cell death-mediated diseases.

HY-B0862

Pendimethalin	Inhibitor	99.75%
Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells.

HY-115532

BCL6-IN-7	Inhibitor	99.79%
BCL6-IN-7 is a potent BCL6−corepressor interaction inhibitor.

HY-100502

CID5721353	Inhibitor	≥98.0%
CID5721353 is an inhibitor of BCL6 with an IC₅₀ value of 212 μM, which corresponds to a K_i of 147 μM.

HY-119402

TP-021	Inhibitor	99.14%
TP-021 (BCL6-IN-8c) is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC₅₀ of 0.10 μM in cell-free enzyme-linked immunosorbent assay.

HY-119931

2-Hydroxychalcone	Inhibitor	98.80%
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

HY-160438B

PBX-7011 TFA	Inhibitor	98.60%
PBX-7011 TFA is a derivative of camptothecin (HY-16560), which inhibits expressions of the cancer related survival genes DDX5, Survivin, Mcl-1 and XIAP in cells FaDu, degrades DDX5 proteins and exhibits anticancer activity.

HY-138697

S65487	Inhibitor	99.91%
S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities.

HY-10087S

Navitoclax-d₈	Inhibitor	99.71%
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].

HY-128553

Antineoplaston A10	Inhibitor	98.09%
Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. Antineoplaston A10 can be used in the study of liver cancer and breast cancer.

HY-142209

ABBV-167	Inhibitor
ABBV-167 is a phosphate proagent of the BCL-2 inhibitor venetoclax.

HY-136640

BCL6-IN-4	Inhibitor	99.72%
BCL6-IN-4 is a potent B-cell lymphoma 6 (BCL6) inhibitor with an IC₅₀ of 97 nM. BCL6-IN-4 has anti-tumor activities.

HY-136774

BCL6-IN-5	Inhibitor	99.82%
BCL6-IN-5 is a potent BCL6 inhibitor exacted from patent WO2018215801A1, example 1n, has a pIC₅₀ of 5.82.

HY-B2046

Simazine	Inhibitor	99.72%
Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.

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